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巯基胆固醇

巯基胆固醇用途

硫胆甾醇是胆甾醇类液晶(CLCs)的一员,可用于合成阳离子脂质。硫胆固醇是银纳米颗粒(SNPs)的一种更强的稳定剂。硫胆固醇可用于质膜研究和药物输送[1][2]。

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巯基胆固醇名称

[ CAS 号 ]:
1249-81-6

[ 中文名 ]:
巯基胆固醇

[ 英文名 ]:
Cholest-5-ene-3-thiol,(3b)-

[英文别名 ]:

EINECS 215-003-4
Cholest-5-ene-3b-thiol
3-thiocholesterol
MFCD00003647
5-CHOLESTEN-3ALPHA-THIOL
THIOCHOLESTEROL SEALED AMPULE
THIOCHOLESTEROL
Cholesteryl mercaptan
cholest-5-ene-3beta-thiol

巯基胆固醇生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Huang Z, et al. Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers. Mol Ther. 2005 Mar;11(3):409-17.

[2]. Ya. A. Gromova, et al. Adsorption Properties of Hybrid Metal–Mesogenic Silver–Cholesterol and Silver–Thiocholesterol Nanosystems. PHYSICAL CHEMISTRY OF NANOCLUSTERS AND NANOMATERIALS. 2019.

巯基胆固醇物理化学性质

[ 密度 ]:
0.98g/cm3

[ 沸点 ]:
482.4ºC at 760mmHg

[ 熔点 ]:
97-99ºC(lit.)

[ 分子式 ]:
C₂₇H₄₆S

[ 分子量 ]:
402.71900

[ 闪点 ]:
224ºC

[ 精确质量 ]:
402.33200

[ PSA ]:
38.80000

[ LogP ]:
8.32620

[ 蒸汽压 ]:
5.38E-09mmHg at 25°C

[ 折射率 ]:
1.53

[ 储存条件 ]:
2-8°C，密封，干燥

巯基胆固醇MSDS

详细MSDS(安全技术说明书)

巯基胆固醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

巯基胆固醇文献

The hedgehog receptor patched is involved in cholesterol transport.

PLoS ONE 6 , e23834, (2011)

Sonic hedgehog (Shh) signaling plays a crucial role in growth and patterning during embryonic development, and also in stem cell maintenance and tissue regeneration in adults. Aberrant Shh pathway act...

Poly(amidoamine) conjugates with disulfide-linked cholesterol pendants self-assembling into redox-sensitive nanoparticles.

Biomacromolecules 9(10) , 2693-704, (2008)

Poly(amidoamine) (PAA) networks that are obtained by the use of cystamine as a cross-linking agent in the reaction with 2,2'-dithiodipyridine turn into linear PAAs with dithiopyridyl side groups that ...

Effect of the nature of the spacer on gene transfer efficacies of novel thiocholesterol derived gemini lipids in different cell lines: a structure-activity investigation.

J. Med. Chem. 51(8) , 2533-40, (2008)

A structure-activity investigation was undertaken to see the effect of the nature of the spacer on the gene transfection efficacies of thiocholesterol-derived cationic gemini lipids possessing disulfi...

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