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β-(氨基甲基)-4 氯代苯乙烷磺酸

β-(氨基甲基)-4 氯代苯乙烷磺酸用途

Saclofen是GABAB受体的竞争性拮抗剂,IC50为7.8μM。Saclofen可用于确定GABAB受体作为大脑中缓慢抑制性突触后电位介质的功能作用[1]。

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β-(氨基甲基)-4 氯代苯乙烷磺酸名称

[ CAS 号 ]:
125464-42-8

[ 中文名 ]:
β-(氨基甲基)-4 氯代苯乙烷磺酸

[ 英文名 ]:
Saclofen

[中文别名 ]:

[英文别名 ]:

Saclofen
3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid
UNII:LRZ36BCQ1Y
MFCD00216817
3-Amino-2-(4-chlorophenyl)-1-propanesulfonic acid

β-(氨基甲基)-4 氯代苯乙烷磺酸生物活性

[ 描述 ]:

Saclofen是GABAB受体的竞争性拮抗剂,IC50为7.8μM。Saclofen可用于确定GABAB受体作为大脑中缓慢抑制性突触后电位介质的功能作用[1]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[参考文献]

[1]. Sallam MY, et al. Central GABAA receptors are involved in inflammatory and cardiovascular consequences of endotoxemia in conscious rats. Naunyn Schmiedebergs Arch Pharmacol. 2016 Mar;389(3):279-88.

β-(氨基甲基)-4 氯代苯乙烷磺酸物理化学性质

[ 密度 ]:
1.437±0.06 g/cm3

[ 熔点 ]:
310-315 ºC

[ 分子式 ]:
C₉H₁₂ClNO₃S

[ 分子量 ]:
249.714

[ 精确质量 ]:
249.022644

[ PSA ]:
88.77000

[ LogP ]:
0.03

[ 外观性状 ]:
白色结晶固体

[ 折射率 ]:
1.600

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
Slightly soluble (7.5 g/L) (25 ºC)

β-(氨基甲基)-4 氯代苯乙烷磺酸MSDS

β-(氨基甲基)-4 氯代苯乙烷磺酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2921499090

β-(氨基甲基)-4 氯代苯乙烷磺酸合成路线

β-(氨基甲基)-4 氯代苯乙烷磺酸上下游产品

β-(氨基甲基)-4 氯代苯乙烷磺酸上游产品

β-(氨基甲基)-4 氯代苯乙烷磺酸下游产品

β-(氨基甲基)-4 氯代苯乙烷磺酸海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

β-(氨基甲基)-4 氯代苯乙烷磺酸文献

Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat.

J. Neurosci. 35(4) , 1723-38, (2015)

The mossy fiber (MF) pathway is critical to hippocampal function and influenced by gonadal hormones. Physiological data are limited, so we asked whether basal transmission and long-term potentiation (...

Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.

Neuroscience 215 , 196-208, (2012)

Spinal cord stimulation (SCS) may alleviate certain forms of neuropathic pain; its mechanisms of action are, however, not fully understood. Previous studies have mainly been focused onto segmental spi...

GABA-induced uncoupling of GABA/benzodiazepine site interactions is associated with increased phosphorylation of the GABAA receptor.

J. Neurosci. Res. 92(8) , 1054-61, (2014)

The use-dependent regulation of the GABAA receptor occurs under physiological, pathological, and pharmacological conditions. Tolerance induced by prolonged administration of benzodiazepines is associa...

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