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脱氧可的松-2,2,4,6,6-d5

脱氧可的松-2,2,4,6,6-d5用途

可的松-d5(11-脱氧可的松-d5)是氘标记的可的松。

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脱氧可的松-2,2,4,6,6-d5名称

[ CAS 号 ]:
1258063-56-7

[ 中文名 ]:
脱氧可的松-2,2,4,6,6-d5

[ 英文名 ]:
Cortodoxone-d5

[英文别名 ]:

Cortexolone-2,2,4,6,6-d5
11-DEOXYCORTISOL-2,2,4,6,6-D5
Reichstein's substance S (2,2,4,6,6-d5)
Cortodoxone-D5 (2,2,4,6,6-D5)
EINECS 200-659-6
11-Deoxy-17-hydroxycorticosterone-2,2,4,6,6-d5
17,21-Dihydroxyprogesterone-2,2,4,6,6-d5
11-Deoxycortisol-D5 (2,2,4,6,6-D5) solution
11-Desoxycortisol-D5 (2,2,4,6,6-D5)
11-Deoxycortisol-D5 (2,2,4,6,6-D5)

脱氧可的松-2,2,4,6,6-d5生物活性

[ 描述 ]:

可的松-d5(11-脱氧可的松-d5)是氘标记的可的松。

[ 相关类别 ]:

研究领域 >> 内分泌

研究领域 >> 炎症/免疫

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体

[体外研究]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

脱氧可的松-2,2,4,6,6-d5物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
524.5±50.0 °C at 760 mmHg

[ 熔点 ]:
208 °C (dec.)

[ 分子式 ]:
C₂₁H₂₅D₅O₄

[ 分子量 ]:
351.491

[ 闪点 ]:
285.1±26.6 °C

[ 精确质量 ]:
351.245789

[ LogP ]:
2.74

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.578

[ 储存条件 ]:
20°C

脱氧可的松-2,2,4,6,6-d5安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

脱氧可的松-2,2,4,6,6-d5文献

An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism.

J. Steroid Biochem. Mol. Biol. 145 , 75-84, (2015)

Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/M...

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