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Odoroside A

Odoroside A用途

Odoroside A 是从夹竹桃叶中提取的一种有效成分。Odoroside A 具有抗癌活性。Odoroside A 通过 ROS/p53 信号通路诱导细胞凋亡和细胞周期阻滞,导致肿瘤细胞死亡。

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Odoroside A名称

[ CAS 号 ]:
12738-19-1

[ 英文名 ]:
Odoroside A

[英文别名 ]:

o-Dopaquinone
odoroside-A
L-dopaquinone
Dopa O-Quinone
DOPA quinone

Odoroside A生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Chen YY, et al. Proteomic Analysis Reveals that Odoroside A Triggers G2/M Arrest and Apoptosis in Colorectal Carcinoma Through ROS-p53 Pathway. Proteomics. 2019;19(15):e1900092.

Odoroside A物理化学性质

[ 密度 ]:
1.22g/cm3

[ 沸点 ]:
662.5ºC at 760mmHg

[ 分子式 ]:
C₃₀H₄₆O₇

[ 分子量 ]:
518.68200

[ 闪点 ]:
211.8ºC

[ 精确质量 ]:
518.32400

[ PSA ]:
94.45000

[ LogP ]:
4.13940

[ 储存条件 ]:
-20°C，避光

Odoroside A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RI3400000

CHEMICAL NAME :: Odoroside A

CAS REGISTRY NUMBER :: 12738-19-1

LAST UPDATED :: 199009

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C30-H46-O7

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 186 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,420,1951 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,192,1963

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Odoroside A

Odoroside A用途

Odoroside A名称

Odoroside A生物活性

Odoroside A物理化学性质

Odoroside A毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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