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N-乙基顺丁烯二酰亚胺

N-乙基顺丁烯二酰亚胺用途

N-Ethylmaleimide (NEM) 是一种半胱氨酸蛋白酶抑制剂。N-Ethylmaleimide 特异性抑制线粒体中的磷酸盐转运。

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N-乙基顺丁烯二酰亚胺名称

[ CAS 号 ]:
128-53-0

[ 中文名 ]:
N-乙基马来酰亚胺

[ 英文名 ]:
N-ethylmaleimide

[中文别名 ]:

[英文别名 ]:

N-ethylmaleimide
EINECS 204-892-4
1H-Pyrrole-2,5-dione, 1-ethyl-
n-ethyl-maleimid
MFCD00005509
1-ethylmaleimide
N-ethyl-maleimide
N-ethylmaleic imide
ethvlmaleimide
n-ethvlmaleimide

N-乙基顺丁烯二酰亚胺生物活性

[ 描述 ]:

N-Ethylmaleimide (NEM) 是一种半胱氨酸蛋白酶抑制剂。N-Ethylmaleimide 特异性抑制线粒体中的磷酸盐转运。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 代谢酶/蛋白酶 >> 组织蛋白酶

[ 靶点 ]

Cysteine protease[1]

[参考文献]

[1]. Wu KH, et al. Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolyticactivity of CvaB, an ATP-binding cassette transporter. J Biol Chem. 2004 Jan 9;279(2):901-9.

[2]. Hatase O , et al. Specific inhibition of phosphate transport in mitochondria by N-ethylmaleimide. Journal of Bioenergetics, 1973, 5(1):1-15.

N-乙基顺丁烯二酰亚胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
210.0±9.0 °C at 760 mmHg

[ 熔点 ]:
43-46 °C(lit.)

[ 分子式 ]:
C₆H₇NO₂

[ 分子量 ]:
125.13

[ 闪点 ]:
73.3±0.0 °C

[ 精确质量 ]:
125.047676

[ PSA ]:
37.38000

[ LogP ]:
0.68

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.514

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.

[ 水溶解性 ]:
1 g/L (20 ºC)

N-乙基顺丁烯二酰亚胺MSDS

N-乙基顺丁烯二酰亚胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9625000

CHEMICAL NAME :: 1H-Pyrrole-2,5-dione, 1-ethyl-

CAS REGISTRY NUMBER :: 128-53-0

BEILSTEIN REFERENCE NO. :: 0112448

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H7-N-O2

MOLECULAR WEIGHT :: 125.14

WISWESSER LINE NOTATION :: T5VNVJ B2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1669 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 750 nmol/L

REFERENCE :: 32YWA5 "Radiation Research, Biomedical, Chemical, and Physical Perspectives, Proceedings of the International Congress of Radiation Research, 5th, Seattle, 1974," Nygaard, O.F., et al., eds., New York, Academic Press, Inc., 1975 Volume(issue)/page/year: -,742,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4314 No. of Facilities: 132 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2547 (estimated) No. of Female Employees: 1922 (estimated)

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N-乙基顺丁烯二酰亚胺安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H311-H314-H317

[ 警示性声明 ]:
P264-P280-P301 + P310-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R20/21;R28;R34;R43

[ 安全声明 (欧洲) ]:
S26-S28-S36/37/39-S45-S28A

[ 危险品运输编码 ]:
UN 2928 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UX9625000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2925190090

N-乙基顺丁烯二酰亚胺合成路线

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N-乙基顺丁烯二酰亚胺海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

N-乙基顺丁烯二酰亚胺文献

RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62.

Biochem. Biophys. Res. Commun. 456(1) , 298-304, (2014)

RIPK3 is a key molecule for necroptosis, initially characterized by necrotic cell death morphology and the activation of autophagy. Cell death and autophagic signaling are believed to tightly regulate...

Extensive diversity of prion strains is defined by differential chaperone interactions and distinct amyloidogenic regions.

PLoS Genet. 10(5) , e1004337, (2014)

Amyloidogenic proteins associated with a variety of unrelated diseases are typically capable of forming several distinct self-templating conformers. In prion diseases, these different structures, call...

Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.

J. Clin. Invest. 125(2) , 831-45, (2015)

Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). PolyQ AR has diminished transc...

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