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10-甲酰叶酸

10-甲酰叶酸用途

10-Formylfolic acid 是二氢叶酸还原酶 (dihydrofolate reductase) 的有效抑制剂。10-Formylfolic acid 可用作白血病的早期指标。

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10-甲酰叶酸名称

[ CAS 号 ]:
134-05-4

[ 中文名 ]:
10-甲酰叶酸

[ 英文名 ]:
10-formylfolic acid (25 mg)

[英文别名 ]:

10-Formylpteroylglutamic Acid
10-Formylfolic acid
N10-Formylfolic Acid

10-甲酰叶酸生物活性

[ 描述 ]:

10-Formylfolic acid 是二氢叶酸还原酶 (dihydrofolate reductase) 的有效抑制剂。10-Formylfolic acid 可用作白血病的早期指标。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 叶酸

[参考文献]

[1]. M D'Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2736-9.

[2]. J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129(7):1315-8.

10-甲酰叶酸物理化学性质

[ 密度 ]:
1.67g/cm3

[ 分子式 ]:
C₂₀H₁₉N₇O₇

[ 分子量 ]:
469.40800

[ 精确质量 ]:
469.13500

[ PSA ]:
221.56000

[ LogP ]:
1.11410

[ 折射率 ]:
1.748

10-甲酰叶酸安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

10-甲酰叶酸文献

Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays.

J. Agric. Food Chem. 50(17) , 4760-8, (2002)

[2H4]Folic acid was synthesized by deuterating p-aminobenzoic acid, which was then coupled to glutamic acid and 6-formylpterin. Using [2H4]folic acid as starting component enabled the preparation of l...

Folate metabolism in man: the effect of malignant disease.

Br. J. Cancer 46(3) , 346-53, (1982)

The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding inclu...

Applicability of alkyl-bonded ultra-pure silica stationary phases for gradient reversed-phase HPLC of folates with conventional and volatile buffers under highly aqueous conditions.

J. Sep. Sci. 29(6) , 889-904, (2006)

Applicability of several alkyl-bonded silica stationary phases was tested for gradient RP-HPLC of folates under highly aqueous conditions. High retention of folates was achieved on alternative phases ...

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