硝呋吡醇

Nifurpirinol (P-7138) 是一种硝基芳香抗生素 (antibiotic),是细菌硝基还原酶 (NTR) 的底物。与甲硝唑相比,Nifurpirinol 是一种更有效的 prodrug,可在表达硝基还原酶的转基因模型中诱导细胞消融。

[ 描述 ]:

[ 相关类别 ]:

[ 靶点 ]

[参考文献]

[ 密度 ]:
1.412 g/cm3

[ 沸点 ]:
416.3ºC at 760 mmHg

[ 熔点 ]:
170-171°

[ 分子式 ]:
C₁₂H₁₀N₂O₄

[ 分子量 ]:
246.21900

[ 闪点 ]:
205.6ºC

[ 精确质量 ]:
246.06400

[ PSA ]:
92.08000

[ LogP ]:
2.76870

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.695

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

UT5023000

CHEMICAL NAME :

2-Pyridinemethanol, 6-(2-(5-nitro-2-furyl)vinyl)-

CAS REGISTRY NUMBER :

13411-16-0

LAST UPDATED :

199612

DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C12-H10-N2-O4

MOLECULAR WEIGHT :

246.24

WISWESSER LINE NOTATION :

T6NJ B1Q F1U1- BT5OJ ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :

Cytogenetic analysis

TEST SYSTEM :

Human Lymphocyte

DOSE/DURATION :

10 umol/L

REFERENCE :

IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921- Volume(issue)/page/year: 48,291,1973

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
UT5023000

[ 海关编码 ]:
2934999090

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Correlation of epizootiological observations with experimental data: chemical induction of chromatophoromas in the croaker, Nibea mitsukurii.

Natl. Cancer Inst. Monogr. 65 , 139-54, (1984)

Chromatophoromas in the croaker nibe, Nibea mitsukurii, are common neoplasms in feral fish which inhabit the shallow water in a unique geographic distribution along the Pacific coast of Japan. We unde...

[Disease of the fins of Rhamdia sapo. Isolation of the etiological agents and experimental infection].

Rev. Argent. Microbiol. 20(1) , 37-48, (1988)

During intensive culture of South-American catfish, Rhamdia sapo fingerlings an epizootic similar to fin rot was developed. Aeromonas hydrophila and Pseudomonas aeruginosa were isolated and they were ...

Mutagenicity of nifurpirinol (P-7138) in Escherichia coli WP2 and Salmonella typhimurium TA100.

Mutat. Res. 104(1-3) , 61-6, (1982)

Nifurpirinol, 6-hydroxymethyl-2-[2-(5-nitro-2-furyl)vinyl]pyridine, which has been widely used as an antibacterial drug against diseases of fish, was found to be a potent mutagen. The mutagenic effect...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：Nifurpirinol

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