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11-叠氮-3,6,9-三氧杂十一烷-1-胺

11-叠氮-3,6,9-三氧杂十一烷-1-胺用途

Amino-PEG3-C2-Azido 是一种基于 PEG 的 PROTAC linker,用于合成 PARP1 降解剂 iRucaparib-TP3.

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11-叠氮-3,6,9-三氧杂十一烷-1-胺名称

[ CAS 号 ]:
134179-38-7

[ 中文名 ]:
1-氨基-11-叠氮-3,6,9-三氧杂十一烷

[ 英文名 ]:
Amino-PEG3-C2-Azido

[中文别名 ]:

[英文别名 ]:

Azido-PEG3-Amine
Amino-PEG3-Azide
2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanamine
1-Amino-11-azido-3,6,9-trioxaundecane
11-Amino-3,6,9-trioxaundecanyl Azide

11-叠氮-3,6,9-三氧杂十一烷-1-胺生物活性

[ 描述 ]:

Amino-PEG3-C2-Azido 是一种基于 PEG 的 PROTAC linker,用于合成 PARP1 降解剂 iRucaparib-TP3.

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[体外研究]

聚甲醛胺(一种CRBN配体和一种已知的免疫调节酰亚胺药物(IMiD))通过三(乙二醇)(PEG3)连接物与Rucaparib结合,得到一种我们称为iRucaparib-TP3的化合物(带有三唑-PEG3连接物的IMiD Rucaparib)。iRucaparib-TP3诱导PARP1降解[1]。

[参考文献]

[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231.

11-叠氮-3,6,9-三氧杂十一烷-1-胺物理化学性质

[ 密度 ]:
1.1

[ 沸点 ]:
198-202ºC

[ 分子式 ]:
C₈H₁₈N₄O₃

[ 分子量 ]:
218.25400

[ 精确质量 ]:
218.13800

[ PSA ]:
103.46000

[ LogP ]:
0.45826

[ 外观性状 ]:
淡黄色油状

[ 折射率 ]:
1.47

[ 储存条件 ]:
Amber Vial, Refrigerator, Under Inert Atmosphere

11-叠氮-3,6,9-三氧杂十一烷-1-胺MSDS

11-叠氮-3,6,9-三氧杂十一烷-1-胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C,Xi

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 海关编码 ]:
2929909090

11-叠氮-3,6,9-三氧杂十一烷-1-胺合成路线

11-叠氮-3,6,9-三氧杂十一烷-1-胺上下游产品

11-叠氮-3,6,9-三氧杂十一烷-1-胺上游产品

11-叠氮-3,6,9-三氧杂十一烷-1-胺下游产品

11-叠氮-3,6,9-三氧杂十一烷-1-胺海关

[ 海关编码 ]: 2929909090

[ 中文概述 ]:
2929909090 其他含氮基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

11-叠氮-3,6,9-三氧杂十一烷-1-胺文献

Cytocompatible in situ forming chitosan/hyaluronan hydrogels via a metal-free click chemistry for soft tissue engineering.

Acta Biomater. 20 , 60-8, (2015)

Injectable hydrogels are important cell scaffolding materials for tissue engineering and regenerative medicine. Here, we report a new class of biocompatible and biodegradable polysaccharide hydrogels ...

Microbial transglutaminase and c-myc-tag: a strong couple for the functionalization of antibody-like protein scaffolds from discovery platforms.

ChemBioChem. 16(5) , 861-7, (2015)

Antibody-like proteins selected from discovery platforms are preferentially functionalized by site-specific modification as this approach preserves the binding abilities and allows a side-by-side comp...

Synthesis of "click" alginate hydrogel capsules and comparison of their stability, water swelling, and diffusion properties with that of Ca(+2) crosslinked alginate capsules.

J. Biomed. Mater. Res. B. Appl. Biomater. 103 , 1120-32, (2015)

Ionically crosslinked alginate hydrogels have been extensively explored for encapsulation and immunoisolation of living cells/tissues to develop implantable cell therapies, such as islet encapsulation...

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