钙蛋白酶抑制剂II(进口)

钙蛋白酶抑制剂II(进口)用途

A potent, cell-permeable calpain inhibitor with Ki of 0.6 and 100 nM for calpain L and calpain B, respectively; inhibits the activities of Ca(2+)-dependent neutral proteases as well as lysosomal proteases, including cathepsin L, cathepsin B, and cathepsin D; induce apoptosis in rat pituitary tumor cells by specific caspase activation.

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钙蛋白酶抑制剂II(进口)名称

[ CAS 号 ]:
136632-32-1

[ 中文名 ]:
钙蛋白酶抑制剂II(进口)

[ 英文名 ]:
ALLM

[英文别名 ]:

MFCD00065506

钙蛋白酶抑制剂II(进口)物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
676.5±55.0 °C at 760 mmHg

[ 分子式 ]:
C₁₉H₃₅N₃O₄S

[ 分子量 ]:
401.564

[ 闪点 ]:
362.9±31.5 °C

[ 精确质量 ]:
401.234833

[ LogP ]:
2.64

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.496

[ 储存条件 ]:
20°C

钙蛋白酶抑制剂II(进口)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22;S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

钙蛋白酶抑制剂II(进口)文献

Compartmentalization of the chick cerebellar cortex based on the link between the striped expression pattern of aldolase C and the topographic olivocerebellar projection.

J. Comp. Neurol. 523 , 1886-912, (2015)

The avian cerebellum is organized into multiple longitudinal stripes defined by expression profiles of aldolase C (zebrin II) in Purkinje cells. The relationship between the aldolase C striped pattern...

Targeting microparticle biogenesis: a novel approach to the circumvention of cancer multidrug resistance.

Curr. Cancer Drug Targets 15 , 205-14, (2015)

Microparticles (MPs) are released from most eukaryotic cells after the vesiculation of the plasma membrane and serve as vectors of long and short-range signaling. MPs derived from multidrug resistant ...

Increased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis.

PLoS ONE 10 , e0136615, (2015)

Childhood acute lymphoblastic leukemia (ALL) blasts are characterized by inhibited apoptosis promoting fast disease progress. It is known that in chronic lymphocytic and acute myeloid leukemias the re...

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