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钙蛋白酶抑制剂I

钙蛋白酶抑制剂I用途

MG-101是有效的半胱氨酸蛋白酶抑制剂,抑制钙蛋白酶I,钙蛋白酶II,组织蛋白酶B和组织蛋白酶L的Ki分别为190,220,150和500 pM。

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钙蛋白酶抑制剂I名称

[ CAS 号 ]:
110044-82-1

[ 中文名 ]:
钙蛋白酶抑制剂I

[ 英文名 ]:
Calpain Inhibitor I

[英文别名 ]:

Ac-Leu-Leu-Nle-H
AC-LL-NORLEUCINAL
AC-LEU-LEU-NORLEUCINAL
Ac-Leu-Leu-Nle-al
Calpain Inhibitor I,ALLN
CALPAIN INHIBITOR I
MG 101
ALLN
ac-llnl-cho
AC-LEU-LEU-NLE-CHO

钙蛋白酶抑制剂I生物活性

[ 描述 ]:

MG-101是有效的半胱氨酸蛋白酶抑制剂,抑制钙蛋白酶I,钙蛋白酶II,组织蛋白酶B和组织蛋白酶L的Ki分别为190,220,150和500 pM。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体

研究领域 >> 癌症

[参考文献]

[1]. Li SZ, et al. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochem Biophys Res Commun. 2013 Jul 26;437(2):325-330.

[相关活性小分子]

钙蛋白酶抑制剂I物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
632.2±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₃₇N₃O₄

[ 分子量 ]:
383.526

[ 闪点 ]:
192.9±30.3 °C

[ 精确质量 ]:
383.278412

[ PSA ]:
104.37000

[ LogP ]:
3.37

[ 外观性状 ]:
powder | white

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.474

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
DMSO: soluble | Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.

钙蛋白酶抑制剂IMSDS

详细MSDS(安全技术说明书)

钙蛋白酶抑制剂I安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

钙蛋白酶抑制剂I文献

Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.

PLoS ONE 10(3) , e0119423, (2015)

Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In...

The role of proteases in excitation-contraction coupling failure in muscular dystrophy.

Am. J. Physiol. Cell Physiol. 308(1) , C33-40, (2015)

Duchenne muscular dystrophy (DMD) is one of the most frequent types of muscular dystrophy. Alterations in intracellular calcium (Ca(2+)) handling are thought to contribute to the disease severity in D...

Necrosis- and apoptosis-related Met cleavages have divergent functional consequences.

Cell Death Dis. 6 , e1769, (2015)

Upon activation by its ligand hepatocyte growth factor/scatter factor, the receptor tyrosine kinase Met promotes survival, proliferation, and migration of epithelial cells during embryogenesis. Deregu...

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