2-(3-吡唑基)乙胺二盐酸盐

2-(3-吡唑基)乙胺二盐酸盐用途

Betazole (Ametazole) dihydrochloride 是一种吡唑类组胺,是一种口服活性 H2 受体激动剂。Betazole dihydrochloride 诱导胃酸分泌,导致胆总管压力立即显著升高。Betazole dihydrochloride 被用作一种被称为 histalog 的诊断剂,用于研究胃酸分泌能力。

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2-(3-吡唑基)乙胺二盐酸盐名称

[ CAS 号 ]:
138-92-1

[ 中文名 ]:
盐酸倍他唑

[ 英文名 ]:
Betazole dihydrochloride

[英文别名 ]:

1h-pyrazole-3-ethanamine,dihydrochloride
BETAZOLE HYDROCHLORIDE (200 MG)
3-(2-aminoethyl)-pyrazoldihydrochloride
histalog
[2-(1H-Pyrazol-3-yl)ethyl]amine dihydrochloride
ametazoledihydrochloride
Betazole hydrochloride
2-(1(2)H-pyrazol-3-yl)-ethylamine,dihydrochloride
gastramine
2-(1(2)H-Pyrazol-3-yl)-aethylamin,Dihydrochlorid

2-(3-吡唑基)乙胺二盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 代谢疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

[ 靶点 ]

H2 Receptor

[体外研究]

盐酸倍他唑(Ametazole)是一种弱组胺激动剂,对H2受体有相对选择性,H1活性最低。盐酸倍他唑诱导胃抑制肽(GIP)分泌[1]。

[参考文献]

[1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521.

[2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382.

[3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909.

2-(3-吡唑基)乙胺二盐酸盐物理化学性质

[ 沸点 ]:
284.1ºC at 760mmHg

[ 熔点 ]:
224-226°

[ 分子式 ]:
C₅H₁₁Cl₂N₃

[ 分子量 ]:
184.06700

[ 闪点 ]:
150.3ºC

[ 精确质量 ]:
183.03300

[ PSA ]:
54.70000

[ LogP ]:
2.21520

[ 蒸汽压 ]:
0.00303mmHg at 25°C

[ 储存条件 ]:
2-8°C

2-(3-吡唑基)乙胺二盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ5600000

CHEMICAL NAME :: Pyrazole, 3-(2-aminoethyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 138-92-1

LAST UPDATED :: 199404

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C5-H9-N3.2Cl-H

MOLECULAR WEIGHT :: 184.09

WISWESSER LINE NOTATION :: T5MNJ C2Z &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Ocular

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 740 ug/kg/37D-I

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human)

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 102,275,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Ocular

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 86 ug/kg/6D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 102,274,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 122,685,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 803 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,749,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83995 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 66 (estimated)

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2-(3-吡唑基)乙胺二盐酸盐安全信息

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933199090

2-(3-吡唑基)乙胺二盐酸盐海关

[ 海关编码 ]: 2933199090

[ 中文概述 ]:
2933199090. 其他结构上有非稠合吡唑环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%