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呋喃他酮

呋喃他酮用途

Furaltadone 是一种硝基呋喃药,可用于肠沙门氏菌感染的研究。Furaltadone 具有体外抑制葡萄球菌的作用。

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呋喃他酮名称

[ CAS 号 ]:
139-91-3

[ 中文名 ]:
呋喃它酮

[ 英文名 ]:
Furaltadone

[中文别名 ]:

呋喃他酮

[英文别名 ]:

Furmethonol
Furaltadone
Altabactina
Furazolin
nf260
Darifur
Sepsinol
Medifuran
ibifur
MFCD00057356

呋喃他酮生物活性

[ 描述 ]:

Furaltadone 是一种硝基呋喃药,可用于肠沙门氏菌感染的研究。Furaltadone 具有体外抑制葡萄球菌的作用。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. A.Rampling(Dr.), et al. The effect of furaltadone, a nitrofuran drug, on experimental infections of chickens with salmonella enteritidis phage Type 4. Pathology Volume 25, Supplement 1, 1993, Page 22.

[2]. William R. McCabe, et al. Furaltadone — A Critical Evaluation of Clinical and Laboratory Studies. N Engl J Med 1960; 263:927-934.

呋喃他酮物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
461.4±55.0 °C at 760 mmHg

[ 熔点 ]:
206ºC (dec.)

[ 分子式 ]:
C₁₃H₁₆N₄O₆

[ 分子量 ]:
324.289

[ 闪点 ]:
232.8±31.5 °C

[ 精确质量 ]:
324.106995

[ PSA ]:
113.33000

[ LogP ]:
-0.84

[ 外观性状 ]:
黄色结晶固体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.669

[ 储存条件 ]:
2-8°C

呋喃他酮MSDS

呋喃他酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ3620000

CHEMICAL NAME :: 2-Oxazolidinone, 5-(morpholinomethyl)-3-((5-nitrofurfurylidene)amino)-

CAS REGISTRY NUMBER :: 139-91-3

BEILSTEIN REFERENCE NO. :: 0363627

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C13-H16-N4-O6

MOLECULAR WEIGHT :: 324.33

WISWESSER LINE NOTATION :: T5OJ BNW E1UN- AT5NVOTJ D1- AT6N DOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 5 mg/L

REFERENCE :: CUMIDD Current Microbiology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978- Volume(issue)/page/year: 10,19,1984

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呋喃他酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
3-26

[ 危险品运输编码 ]:
UN 3249

[ WGK德国 ]:
3

[ RTECS号 ]:
RQ3620000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2934992000

呋喃他酮合成路线

呋喃他酮上下游产品

呋喃他酮上游产品

呋喃他酮下游产品

呋喃他酮海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

呋喃他酮文献

Elucidating the regulon of multidrug resistance regulator RarA in Klebsiella pneumoniae.

Antimicrob. Agents Chemother. 57(4) , 1603-9, (2013)

RarA is an AraC-type regulator in Klebsiella pneumoniae, which, when overexpressed, confers a low-level multidrug-resistant (MDR) phenotype linked to the upregulation of both the acrAB and oqxAB efflu...

Development of a competitive ELISA for the detection of a furaltadone marker residue, 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), in cultured fish samples.

J. Vet. Med. Sci. 74(11) , 1439-46, (2012)

This report describes an enzyme-linked immunosorbent assay (ELISA) for tissue-bound metabolite 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ) and the application to residue analysis in cultured fis...

Cloning, expression, purification, and characterization of a novel single-chain variable fragment antibody against the 2-nitrobenzaldehyde derivative of a furaltadone metabolite in Escherichia coli.

Protein Expr. Purif. 84(1) , 140-6, (2012)

Furaltadone is an illicit veterinary drug that shows toxic, carcinogenic, and mutagenic effects, as does its metabolite 3-amino-5-morpholinomethyl-2-oxazolidone (AMOZ)(1). Recombinant antibodies with ...

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