1-Phenazinol,6-methoxy-, 5,10-dioxide

1-Phenazinol,6-methoxy-, 5,10-dioxide用途

粘菌素是一种由抗微生物溶杆菌OH13产生的二氮氧化物吩嗪。粘菌素对许多微生物和肿瘤细胞有毒[1]。

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1-Phenazinol,6-methoxy-, 5,10-dioxide名称

[ CAS 号 ]:
13925-12-7

[ 英文名 ]:
1-Phenazinol,6-methoxy-, 5,10-dioxide

[英文别名 ]:

Myxin
6-Methoxy-1-phenazinol 5,10-dioxide
1-Hydroxy-6-methoxyphenazine 5,10-dioxide
1-hydroxy-6-methoxyphenazine N5,N10-dioxide
3C Antibiotic
1-Phenazinol,6-methoxy-,5,10-dioxide
6-methoxy-5,10-dioxy-phenazin-1-ol
1-Methoxy-6-hydroxyphenazin-5,10-dioxid

1-Phenazinol,6-methoxy-, 5,10-dioxide生物活性

[ 描述 ]:

粘菌素是一种由抗微生物溶杆菌OH13产生的二氮氧化物吩嗪。粘菌素对许多微生物和肿瘤细胞有毒[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Liu J, et al. Monooxygenase LaPhzX is Involved in Self-Resistance Mechanisms during the Biosynthesis of N-Oxide Phenazine Myxin. J Agric Food Chem. 2021;69(45):13524-13532.

1-Phenazinol,6-methoxy-, 5,10-dioxide物理化学性质

[ 密度 ]:
1.53g/cm3

[ 沸点 ]:
538.8ºC at 760mmHg

[ 分子式 ]:
C₁₃H₁₀N₂O₄

[ 分子量 ]:
258.23000

[ 闪点 ]:
279.7ºC

[ 精确质量 ]:
258.06400

[ PSA ]:
80.38000

[ LogP ]:
2.56420

[ 蒸汽压 ]:
1.93E-12mmHg at 25°C

[ 折射率 ]:
1.73

1-Phenazinol,6-methoxy-, 5,10-dioxide毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SG1660000

CHEMICAL NAME :: 1-Phenazinol, 6-methoxy-, 5,10-dioxide

CAS REGISTRY NUMBER :: 13925-12-7

BEILSTEIN REFERENCE NO. :: 0622031

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H10-N2-O4

MOLECULAR WEIGHT :: 258.25

WISWESSER LINE NOTATION :: T C666 BN INJ BO DQ IO KO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Protozoa - Euglena gracilis

DOSE/DURATION :: 10 mg/L

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 27,586,1971

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1-Phenazinol,6-methoxy-, 5,10-dioxide安全信息

[ 海关编码 ]:
2933990090

1-Phenazinol,6-methoxy-, 5,10-dioxide合成路线

详细合成路线

1-Phenazinol,6-methoxy-, 5,10-dioxide上下游产品

1-Phenazinol,6-methoxy-, 5,10-dioxide上游产品

1-Phenazinol,6-methoxy-, 5,10-dioxide下游产品

1-Phenazinol,6-methoxy-, 5,10-dioxide海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%