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萝卜硫素

萝卜硫素用途

(R)-Sulforaphane 是一种高效的 Keap1/Nrf2/ARE 途径诱导剂。(R)-Sulforaphane 比 S-异构体更能诱导大鼠肝脏和肺部的致癌解毒酶系统。

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萝卜硫素名称

[ CAS 号 ]:
142825-10-3

[ 中文名 ]:
L-萝卜硫素

[ 英文名 ]:
L-Sulforaphane

[英文别名 ]:

UNII:41684WL1GL
1-Isothiocyanato-4-(methylsulfinyl)butane
SULFORAPHANE, (±)-
4-Isothiocyanatobutyl methyl sulfoxide
4-Methylsulfinylbutyl isothiocyanate
1-Isothiocyanato-4-[(R)-methylsulfinyl]butane
4-(Methylsulfinyl)butyl isothiocyanate
Butane, 1-isothiocyanato-4-(methylsulfinyl)-
(R)-sulforaphane
MFCD09039283

萝卜硫素生物活性

[ 描述 ]:

(R)-Sulforaphane 是一种高效的 Keap1/Nrf2/ARE 途径诱导剂。(R)-Sulforaphane 比 S-异构体更能诱导大鼠肝脏和肺部的致癌解毒酶系统。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. De Nicola GR, et al. Novel gram-scale production of enantiopure R-sulforaphane from Tuscan black kale seeds. Molecules. 2014 May 27;19(6):6975-86.

[2]. Abdull Razis AF, et al. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer. 2011 Jun 15;128(12):2775-82.

萝卜硫素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
368.2±25.0 °C at 760 mmHg

[ 分子式 ]:
C₆H₁₁NOS₂

[ 分子量 ]:
177.288

[ 闪点 ]:
176.5±23.2 °C

[ 精确质量 ]:
177.028198

[ PSA ]:
80.73000

[ LogP ]:
0.23

[ 外观性状 ]:
透明淡黄色油状

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.567

[ 储存条件 ]:
-20°C

萝卜硫素MSDS

萝卜硫素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S23-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2930909090

萝卜硫素合成路线

萝卜硫素上下游产品

萝卜硫素上游产品

萝卜硫素下游产品

萝卜硫素海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

萝卜硫素文献

Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells.

Int. J. Mol. Med. 36 , 53-64, (2015)

Sulforaphane, a natural isothiocyanate compound found in cruciferous vegetables, has been shown to exert cardioprotective effects during ischemic heart injury. However, the effects of sulforaphane on ...

In vitro metabolic conversion of the organic breakdown products of glucosinolate to goitrogenic thiocyanate anion.

J. Sci. Food Agric. 95 , 2244-51, (2015)

Glucosinolates are abundant in Brassicaceae vegetables, and they are degraded into various organic breakdown products (BPs) (R-CN, -NCS and -SCN) by myrosinase when plant tissues are damaged. This stu...

Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations.

Cancer Res. 75 , 4817-29, (2015)

Pharmacologic activation of the transcription factor NRF2 has been suggested to offer a strategy for cancer prevention. In this study, we present evidence from murine tumorigenesis experiments suggest...

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