< 生产厂家价格 >

Perzinfotel

Perzinfotel用途

Perzinfotel (EAA-090) 是一种有效选择性的,竞争性的 NMDA 受体拮抗剂,具有神经保护作用。Perzinfotel (EAA-090) 对谷氨酸位点显示出高亲和力 (IC50=30 nM)。

点击显示

Perzinfotel名称

[ CAS 号 ]:
144912-63-0

[ 英文名 ]:
Perzinfotel

[英文别名 ]:

Perzinfotel生物活性

[ 描述 ]:

Perzinfotel (EAA-090) 是一种有效选择性的,竞争性的 NMDA 受体拮抗剂,具有神经保护作用。Perzinfotel (EAA-090) 对谷氨酸位点显示出高亲和力 (IC50=30 nM)。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[ 靶点 ]

NMDA receptor[1]

[体外研究]

Perzinfotel阻断NMDA诱导的电流,IC50为0.48μm,谷氨酸诱导的神经毒性,IC50为1.6μm[1]。

[参考文献]

[1]. Brandt MR, et al. Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity. J Pharmacol Exp Ther. 2005 Jun;313(3):1379-86.

[2]. Kinney WA, et al. Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid(EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere. J Med Chem. 1998 Jan 15;41(2):236-46.

Perzinfotel物理化学性质

[ 分子式 ]:
C₉H₁₃N₂O₅P

[ 分子量 ]:
260.18400

[ 精确质量 ]:
260.05600

[ PSA ]:
116.75000

PerzinfotelMSDS

详细MSDS(安全技术说明书)

Perzinfotel安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

Perzinfotel文献

Characterization of two novel N-methyl-D-aspartate antagonists: EAA-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318 (R-alpha-amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic acid hydrochloride).

J. Pharmacol. Exp. Ther. 310(2) , 563-70, (2004)

Two novel N-methyl-d-aspartate (NMDA) antagonists with unique chemical structures, EAA-090 (2-[8,9-dioxo-2, 6-diazabicyclo[5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318 (R-alpha-amino-5-chlo...

Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons.

Naunyn Schmiedebergs Arch. Pharmacol. 385(2) , 171-80, (2012)

GluN receptors are heteromers of obligatory GluN1 subunits and GluN2(A-D) subunits. In the present study, we addressed the question whether GluN2A and GluN2B subunits play distinct roles in the format...

更多文献