ω-Agatoxin IVA

ω-Agatoxin IVA用途

ω-Agatoxin IVA 是一种有效的选择性 P/Q型 Ca2+ 通道阻滞剂,对于 P 型和 Q 型 Ca2+ 通道,IC50 分别为 2 nM 和 90 nM。ω-Agatoxin IVA (IC50,30-225 nM) 抑制高钾引起的谷氨酸胞吐作用和钙流入。ω-Agatoxin IVA 还可以阻止高钾诱导的 5-羟色胺和去甲肾上腺素的释放,对 L 型或 N 型钙通道没有影响。

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ω-Agatoxin IVA名称

[ CAS 号 ]:
145017-83-0

[ 中文名 ]:
OMEGA-漏斗网蛛毒素 IVA

[ 英文名 ]:
ω-Agatoxin IVa trifluoroacetate salt

ω-Agatoxin IVA生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 神经疾病

[ 靶点 ]

IC50: 2 nM (P-type Ca2+ channels), 90 nM (Q-type Ca2+ channels)[1]

[参考文献]

[1]. T Teramoto, et al. A novel type of calcium channel sensitive to omega-agatoxin-TK in cultured rat cerebral cortical neurons. Brain Res. 1997 May 9;756(1-2):225-30.

[2]. M Kimura, et al. Involvement of P-type calcium channels in high potassium-elicited release of neurotransmitters from rat brain slices. Neuroscience. 1995 Jun;66(3):609-15.

ω-Agatoxin IVA物理化学性质

[ 分子式 ]:
C₂₁₇H₃₆₀N₆₈O₆₀S₁₀

[ 储存条件 ]:
-20°C，密封，干燥，惰性气体

ω-Agatoxin IVA安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

ω-Agatoxin IVA文献

P-type calcium channels blocked by the spider toxin omega-Aga-IVA.

Nature 355 , 827-829, (1992)

Voltage-dependent calcium channels mediate calcium entry into neurons, which is crucial for many processes in the brain including synaptic transmission, dendritic spiking, gene expression and cell dea...

P-type calcium channels in rat central and peripheral neurons.

Neuron 9 , 85-95, (1992)

The peptide toxin omega-Aga-IVA blocked P-type Ca2+ channel current in rat Purkinje neurons (KD approximately 2 nM) but had no effect on identified T-type, L-type, or N-type currents in a variety of c...

Calcium channels coupled to glutamate release identified by omega-Aga-IVA.

Science 258 , 310-313, (1992)

Presynaptic calcium channels are crucial elements of neuronal excitation-secretion coupling. In mammalian brain, they have been difficult to characterize because most presynaptic terminals are too sma...

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