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3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯

3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯用途

noc18是一氧化氮供体,在培养的大鼠小脑颗粒细胞中激活内向电流。noc18增加培养的血管平滑肌细胞cGMP的产生。noc18降低体外心肌制剂的收缩性。

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3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯名称

[ CAS 号 ]:
146724-94-9

[ 中文名 ]:
NOC-18

[ 英文名 ]:
DETA-NONOate

[中文别名 ]:

[英文别名 ]:

1,1-Bis(2-aminoethyl)-2-hydroxy-3-oxotriazane
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene
N-[bis(2-aminoethyl)amino]-N-hydroxynitrous amide
MFCD00278808
Diethylenetriamine nitric oxide adduct
DETA NONOate
2,2'-(hydroxynitrosohydrazono)bis-ethanamine

3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯生物活性

[ 描述 ]:

noc18是一氧化氮供体,在培养的大鼠小脑颗粒细胞中激活内向电流。noc18增加培养的血管平滑肌细胞cGMP的产生。noc18降低体外心肌制剂的收缩性。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
303.0±52.0 °C at 760 mmHg

[ 熔点 ]:
98-106ºC

[ 分子式 ]:
C₄H₁₃N₅O₂

[ 分子量 ]:
163.178

[ 闪点 ]:
137.1±30.7 °C

[ 精确质量 ]:
163.106918

[ PSA ]:
108.18000

[ LogP ]:
-1.65

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.588

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: >20 mg/mL

3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯MSDS

3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
KH2502500

[ 海关编码 ]:
2928000090

3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯合成路线

3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯上下游产品

3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯上游产品

3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯下游产品

3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

3,3-二(氨乙基)-1-羟基-2-羰基-1-三氮烯文献

In vivo imaging of reactive oxygen species in mouse brain by using [3H]hydromethidine as a potential radical trapping radiotracer.

J. Cereb. Blood Flow Metab. 34(12) , 1907-13, (2014)

To assess reactive oxygen species (ROS) production by detecting the fluorescent oxidation product, hydroethidine has been used extensively. The present study was undertaken to evaluate the potential o...

Regulation of microglial migration, phagocytosis, and neurite outgrowth by HO-1/CO signaling.

Dev. Neurobiol. 75 , 854-76, (2015)

Clearance of infected and apoptotic neuronal corpses during inflammatory conditions is a fundamental process to create a favorable environment for neuronal recovery. Microglia are the resident immune ...

Preservation of nitric oxide-induced relaxation of porcine coronary artery: roles of the dimers of soluble guanylyl cyclase, phosphodiesterase type 5, and cGMP-dependent protein kinase.

Pflugers Arch. 466(10) , 1999-2008, (2014)

Soluble guanylyl cyclase (sGC), phosphodiesterase type 5 (PDE5), and guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (PKG) are all dimeric. The present study was to determine the ...

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