8-(3-Chlorostyryl)caffeine

8-(3-Chlorostyryl)caffeine用途

(E) -8-(3-氯苯乙烯基)咖啡因是一种选择性腺苷A2A受体拮抗剂。(E) -8-(3-氯苯乙烯基)咖啡因通过独立于其对A2A受体的作用的途径抑制Ki值为70 nM的单胺氧化酶B(MAO-B)。(E) -8-(3-氯苯乙烯基)咖啡因有可能用于帕金森病研究[1]。

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8-(3-Chlorostyryl)caffeine名称

[ CAS 号 ]:
147700-11-6

[ 英文名 ]:
8-(3-Chlorostyryl)caffeine

[英文别名 ]:

(E)-8-(3-chlorostyryl)-1,3,7-trimethylxanthine
8-(3-Chlorostyryl)caffeine
(E)-1,3,7-trimethyl-8-(3-chlorostyryl)xanthine
(E)-8-(3,4-Dimethoxystyryl)-1,3-diethylxanthine
8-(3-chloro-(E)-styryl)caffeine

8-(3-Chlorostyryl)caffeine生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 单胺氧化酶

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

[ 靶点 ]

A2AR

MAO-B:70 nM (Ki)

[参考文献]

[1]. Nevil Vlok, et al. Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC). Bioorg Med Chem. 2006 May 15;14(10):3512-21.

8-(3-Chlorostyryl)caffeine物理化学性质

[ 密度 ]:
1.36g/cm3

[ 沸点 ]:
559.4ºC at 760 mmHg

[ 分子式 ]:
C₁₆H₁₅ClN₄O₂

[ 分子量 ]:
330.76900

[ 闪点 ]:
292.1ºC

[ 精确质量 ]:
330.08800

[ PSA ]:
61.82000

[ LogP ]:
1.79450

[ 蒸汽压 ]:
1.52E-12mmHg at 25°C

[ 折射率 ]:
1.656

8-(3-Chlorostyryl)caffeine安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

8-(3-Chlorostyryl)caffeine文献

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