2-巯基苯并噻唑
2-巯基苯并噻唑用途
2-巯基苯并噻唑名称
[ CAS 号 ]:
149-30-4
[ 中文名 ]:
2-巯基苯并噻唑
[ 英文名 ]:
2-Mercaptobenzothiazole
[中文别名 ]:
[英文别名 ]:
- AG 63
- T56 BMYSJ CUS
- ROTAX
- 2-Benzothiazolethiol,MBT
- 2-mercapto-benzothiazole
- 2-Benzothiazolethiol (MBT)
- 2-sulfanyl-1,3-benzothiazole
- 2-MBT
- Sulfur Accelerator M
- CAPTAX
2-巯基苯并噻唑生物活性
2-巯基苯并噻唑物理化学性质
[ 密度 ]:
1.5±0.1 g/cm3
[ 沸点 ]:
305.0±25.0 °C at 760 mmHg
[ 熔点 ]:
177-181 °C(lit.)
[ 分子式 ]:
C7H5NS2
[ 分子量 ]:
167.251
[ 闪点 ]:
243 ºC (dec.)
[ 精确质量 ]:
166.986343
[ PSA ]:
79.93000
[ LogP ]:
2.38
[ 外观性状 ]:
米色或淡黄色粉末带有一种微弱气味
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.784
[ 储存条件 ]:
通风低温干燥,与库房食品原料,酸类和氧化剂分开存放
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Flammable.
[ 水溶解性 ]:
<0.1 g/100 mL at 19 ºC
2-巯基苯并噻唑MSDS
2-巯基苯并噻唑毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DL6475000
- CHEMICAL NAME :
- 2-Benzothiazolethiol
- CAS REGISTRY NUMBER :
- 149-30-4
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 29
- MOLECULAR FORMULA :
- C7-H5-N-S2
- MOLECULAR WEIGHT :
- 167.25
- WISWESSER LINE NOTATION :
- T56 BN DSJ CSH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1270 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1158 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >7940 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - changes in motor activity (specific assay)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- >2150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12220 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 gm/kg/16D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 97500 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 174 gm/kg/86W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 770 mg/kg/7D-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), zonal Liver - liver function tests impaired
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 195 gm/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia Gastrointestinal - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 gm/kg/78W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 215 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 195 gm/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 800 mg/kg
- SEX/DURATION :
- male 2 day(s) pre-mating female 2 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- female 4-11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 4176 mg/kg
- SEX/DURATION :
- female 6-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - gastrointestinal system
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 351 mg/L
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-332,1988 *** REVIEWS *** TOXICOLOGY REVIEW JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968- Volume(issue)/page/year: 15,808,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84030 No. of Facilities: 2428 (estimated) No. of Industries: 45 No. of Occupations: 40 No. of Employees: 42637 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84030 No. of Facilities: 4825 (estimated) No. of Industries: 74 No. of Occupations: 62 No. of Employees: 86509 (estimated) No. of Female Employees: 16409 (estimated)
2-巯基苯并噻唑安全信息
[ 符号 ]:
GHS07, GHS09
[ 信号词 ]:
Warning
[ 危害声明 ]:
H317-H410
[ 警示性声明 ]:
P273-P280-P501
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xi:Irritant
[ 风险声明 (欧洲) ]:
R43;R50/53
[ 安全声明 (欧洲) ]:
S24-S37-S60-S61
[ 危险品运输编码 ]:
UN 3077 9/PG 3
[ WGK德国 ]:
2
[ RTECS号 ]:
DL6475000
[ 包装等级 ]:
I; II; III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
29342020
2-巯基苯并噻唑合成路线
2-巯基苯并噻唑上下游产品
2-巯基苯并噻唑上游产品
2-巯基苯并噻唑下游产品
2-巯基苯并噻唑制备
1. 该品有许多生产方法，但主要是分别以苯胺、邻硝基氯苯和二苯硫脲为原料的3种方法。1.以苯胺为原料 通常是将苯胺、二硫化碳和硫磺在高压釜中直接反应，也可用脂肪胺、二甲基甲酰胺、三噻唑烷和多取甲醛等代替二硫化碳，使苯胺和硫磺的压力下反应。用苯胺为原料的方法，其反应压力都较高，一般在4MPa以上，有高达15MPa，因此也称高压法。
2. 以邻硝基氯苯为原料 邻硝基氯苯与还原剂硫氢化钠、多硫化钠或硫化氢反应都可还原成邻氨基硫酚。进一步与二硫化碳反应而制得促进剂M。这类方法有的反应时间较长（硫氢化钠约需20h），但都可在常压或较低压力下进行，又称常压法。
3. 以二苯硫脲为原料 此法的反应压力介于前述两种方法之间，在4MPa以下，一般称中压法。见水处理剂 03301。
4. 其制备方法是以邻氯硝基苯、多硫化钠、二硫化碳为原料，在110～130℃温度、343kPa压力下反应生成2-巯基苯并噻唑钠盐，再用硫酸进行酸化、水洗得产品。
5. 工业上大多采用邻硝基氯苯法、苯胺法、硝基苯和苯胺混合法三种方法生产。苯胺法合成M是我国各助剂厂普遍采用的方法。在合成釜中投入一定比例的苯胺、CS2和硫黄，在搅拌下升温，在温度240～260℃、压力9.0～10.0MPa下保温反应3h。反应结束后于一定pH值条件下碱溶，除去不溶物，溶液经酸化、脱水和干燥后得到产品促进剂M。也可以采用苯胺为主要原料，先与二硫化碳生成犖取代含硫化合物，再在浓硫酸和溴化钠存在下合环反应得产物，反应均在常温常压下进行，产率达90%。合成反应式如下
6. 常压法 将硫化钠、硫磺制成多硫化钠，然后将多硫化钠、邻硝基氯苯、二硫化碳在100～130℃和低于0.34MPa压力下，缩合成2-巯基苯并噻唑的钠盐。经25%～30%的硫酸进行一次酸化 （ph值2～3） 、水洗 （80℃） 、氢氧化钠碱溶 (ph值11.5～12） 、过滤、硫酸二次酸化 （ 温度60～65℃，ph值4～5） 、中和、水洗、干燥、粉碎，即为成品。
2-巯基苯并噻唑海关
[ 海关编码 ]: 2933199090
[ 中文概述 ]:
2933199090. 其他结构上有非稠合吡唑环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
2-巯基苯并噻唑文献
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 978-979 , 131-7, (2015)
Spermine and spermidine are multiple-nitrogen compounds found in many foods. Both compounds are essential for cell growth and human health. This study established a simple and fast method of detecting...
Simple analytical strategy for MALDI-TOF-MS and nanoUPLC-MS/MS: quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ROS protein indicators reduced by curcumin.Food Chem. 174 , 571-6, (2014)
Curcumin is the major active ingredient of turmeric and is widely used as a preservative, flavouring and colouring agent. Curcumin is a potent substance with several functions, including antioxidant, ...
Rapid and sensitive LC-MS-MS determination of 2-mercaptobenzothiazole, a rubber additive, in human urine.Anal. Bioanal. Chem 407(12) , 3417-23, (2015)
2-Mercaptobenzothiazole (MBT) is one of the most important vulcanization accelerators in the industrial production of rubber, especially car tires. Given its wide use in household articles and industr...
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联系人：徐经理
产品详情：苯并噻唑-2-硫酮
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区域：南通市崇川区
价格：
￥需询单/1kg
￥需询单/1ton
联系人：曹经理
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区域：上海市奉贤区
价格：
￥178.0/500g
联系人：刘佳
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【2-巯基苯并噻唑】化源网提供2-巯基苯并噻唑CAS号149-30-4，2-巯基苯并噻唑MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询2-巯基苯并噻唑上化源网，专业又轻松。>>电脑版：2-巯基苯并噻唑
标题：2-巯基苯并噻唑_MSDS_用途_密度_CAS号【149-30-4】_化源网 地址：https://m.chemsrc.com/mip/cas/149-30-4_311756.html