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苯并噻唑

苯并噻唑用途

Benzothiazole 是一种天然的杂环核。Benzothiazole 杂环核具有抗癌、抗菌、抗糖尿病、抗炎、抗病毒、抗利什曼等多种生物活性。

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苯并噻唑名称

[ CAS 号 ]:
95-16-9

[ 中文名 ]:
苯并噻唑

[ 英文名 ]:
Benzo[d]thiazole

[中文别名 ]:

[英文别名 ]:

1,3-Benzothiazole
benzothiazol
Benzothiazole
(methylthio)benzothiazole
USAF EK-4812
Vangard BT
Benzosulfonazole
benzo[d][1,3]thiazole
1-Thia-3-azaindene
benzthiazole

苯并噻唑生物活性

[ 描述 ]:

Benzothiazole 是一种天然的杂环核。Benzothiazole 杂环核具有抗癌、抗菌、抗糖尿病、抗炎、抗病毒、抗利什曼等多种生物活性。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

研究领域 >> 代谢疾病

[参考文献]

[1]. Ruhi Ali, et al. Biological Aspects of Emerging Benzothiazoles: A Short Review, Journal of Chemistry, vol. 2013, Article ID 345198, 12 pages, 2013.

苯并噻唑物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
227.0±9.0 °C at 760 mmHg

[ 熔点 ]:
2 °C(lit.)

[ 分子式 ]:
C₇H₅NS

[ 分子量 ]:
135.186

[ 闪点 ]:
96.6±7.6 °C

[ 精确质量 ]:
135.014267

[ PSA ]:
41.13000

[ LogP ]:
2.01

[ 外观性状 ]:
黄色液体带有一种令人不愉快的气味

[ 蒸汽密度 ]:
4.66 (vs air)

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.689

[ 储存条件 ]:
通风低温干燥,与库房食品原料分开存放

[ 稳定性 ]:
Stable - regarded as highly persistent in the environment. Incompatible with strong oxidizing agents. Combustion products: nitrogen oxides, carbon monoxide, carbon dioxide, sulphur oxides.

[ 水溶解性 ]:
slightly soluble

苯并噻唑MSDS

详细MSDS(安全技术说明书)

苯并噻唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL0875000

CHEMICAL NAME :: Benzothiazole

CAS REGISTRY NUMBER :: 95-16-9

BEILSTEIN REFERENCE NO. :: 0109468

LAST UPDATED :: 199806

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C7-H5-N-S

MOLECULAR WEIGHT :: 135.19

WISWESSER LINE NOTATION :: T56 BN DSJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534825

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534825 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Lungs, Thorax, or Respiration - pulmonary emboli Liver - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534825

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1400 mg/m3/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-1190-0987S

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 45,189,1932

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - irritability Vascular - regional or general arteriolar or venous dilation

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 45,189,1932

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,249,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 105,486,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 310 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 9(12),11,1975

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Vascular - regional or general arteriolar or venous dilation

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 45,189,1932

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Lungs, Thorax, or Respiration - pulmonary emboli Liver - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534825 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84003 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 69 (estimated)

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苯并噻唑安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311-H319-H332

[ 警示性声明 ]:
P280-P301 + P310-P305 + P351 + P338-P312

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S23-S26-S36-S36/37

[ 危险品运输编码 ]:
2810

[ WGK德国 ]:
2

[ RTECS号 ]:
DL0875000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2934200090

苯并噻唑上下游产品

苯并噻唑上游产品

苯并噻唑下游产品

苯并噻唑制备

【方法一】
由邻氨基苯基硫化锌与甲酸的混合物回流加热后，反应产物进行水蒸气蒸馏而得。
由甲酰替苯胺或二甲基苯胺与硫一起加热而成。
由2-巯基苯并噻唑或相应的二硫化物进行氧化反应而得。
【方法二】
由N,N-二甲基苯胺与硫磺反应而得。将N,N-二甲基苯胺和硫磺一起加热回流，反应8h后蒸馏。收集200-260℃馏分，将其溶于浓盐酸中，过滤。向滤液加入硝酸铵水溶液，析出苯并噻唑硝酸盐，过滤后将滤饼溶于水中，加氨水至碱性，析出结晶，过滤干燥后减压蒸馏，收集131℃（4.53kPa）馏分即得成品。

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苯并噻唑海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

苯并噻唑文献

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Benzothiazole, benzotriazole, and their derivates in clothing textiles--a potential source of environmental pollutants and human exposure.

Environ. Sci. Pollut. Res. Int. 22(8) , 5842-9, (2015)

Textiles play an important role in our daily life, and textile production is one of the oldest industries. In the manufacturing chain from natural and/or synthetic fibers to the final clothing product...

Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives.

Bioorg. Med. Chem. Lett. 23(1) , 287-90, (2013)

Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg yo...

更多文献

苯并噻唑

苯并噻唑用途

苯并噻唑名称

苯并噻唑生物活性

苯并噻唑物理化学性质

苯并噻唑MSDS

详细MSDS(安全技术说明书)

苯并噻唑毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

苯并噻唑安全信息

苯并噻唑上下游产品

苯并噻唑上游产品

苯并噻唑下游产品

苯并噻唑制备

苯并噻唑海关

苯并噻唑文献

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