< 生产厂家价格 >

羟甲唑啉

羟甲唑啉用途

羟甲唑啉是一种α-肾上腺素受体激动剂,α1A、α1B、α2A和α2C的IC50s分别为0.02μM、0.25μM、o.58μM和0.13μM。奥昔他唑啉可用于研究鼻粘膜的解充血作用[1]。

点击显示

羟甲唑啉名称

[ CAS 号 ]:
1491-59-4

[ 中文名 ]:
羟甲唑啉

[ 英文名 ]:
Oxymetazoline

[中文别名 ]:

[英文别名 ]:

Oximetazolinum
EINECS 216-079-1
Rhinofrenol
MFCD00242798
Iliadin
Oxymethazoline
Sinerol
Oxylazine
Nezeril
Hazol

羟甲唑啉生物活性

[ 描述 ]:

羟甲唑啉是一种α-肾上腺素受体激动剂,α1A、α1B、α2A和α2C的IC50s分别为0.02μM、0.25μM、o.58μM和0.13μM。奥昔他唑啉可用于研究鼻粘膜的解充血作用[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

[ 靶点 ]

IC50: 0.02 μM (α1A), 0.25 μM (α1B), 0.58 μM (α2A), 0.13 μM (α2C)[1]

[参考文献]

[1]. Haenisch B, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.

羟甲唑啉物理化学性质

[ 密度 ]:
1.08 g/cm3

[ 沸点 ]:
431.9ºC at 760 mmHg

[ 熔点 ]:
182ºC

[ 分子式 ]:
C₁₆H₂₄N₂O

[ 分子量 ]:
260.37500

[ 闪点 ]:
215ºC

[ 精确质量 ]:
260.18900

[ PSA ]:
44.62000

[ LogP ]:
2.61510

[ 蒸汽压 ]:
4.59E-08mmHg at 25°C

羟甲唑啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SK1050000

CHEMICAL NAME :: Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-

CAS REGISTRY NUMBER :: 1491-59-4

BEILSTEIN REFERENCE NO. :: 0886303

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H24-N2-O

MOLECULAR WEIGHT :: 260.42

WISWESSER LINE NOTATION :: T5M CN BUTJ B1R CQ B1 F1 DX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,74,1967 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 20 mg/kg

SEX/DURATION :: female 1-5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 11,563,1975

点击显示

羟甲唑啉安全信息

[ 危险品运输编码 ]:
UN 3249

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
2933290090

羟甲唑啉海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%