PD-85639
PD-85639用途
PD-85639 is a voltage-gated sodium (Na+) channel blocker (75% in 10 min & >95% in 25 min blockage of Na+ current by 25 μM PD85,639; whole-cell patch clamp using primary rat brain neurons) that is shown to target rat brain Nav1.2 with simultaneous high- and low-affinity modes of binding (EC50 = 56 nM/40% & 20 μM/60% at pH 9.0, 5 nM/28% & 3 μM/72% at pH 7.4, against 2 nM [3H]-PD85,639 for binding rat brain synaptosomes; EC50 = 17 nM/39% & 10 μM/61% using at pH 9.0 using rat brain synaptosome membranes) and a fast kinetic (t1/2 = 1.2 at 4°C, <0.5 min at 25°C), competitive against the local anesthetic Na+ channel blockers tetracaine, bupivacaine, and mepivacaine, as well as Na+ channel activators veratridine and batrachotoxin (K1 = 0.26 μM against 5 nM [3H]-BTX for binding rat neocrotical membranes).
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PD-85639名称
[ CAS 号 ]:
149838-21-1
[ 英文名 ]:
PD-85639
PD-85639物理化学性质
[ 密度 ]:
1.06g/cm3
[ 沸点 ]:
562.1ºC at 760 mmHg
[ 分子式 ]:
C23H31N3O
[ 分子量 ]:
365.51200
[ 闪点 ]:
293.8ºC
[ 精确质量 ]:
365.24700
[ PSA ]:
59.35000
[ LogP ]:
4.98820
[ 蒸汽压 ]:
1.16E-12mmHg at 25°C
[ 折射率 ]:
1.552
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相关化合物
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标题:149838-21-1_PD-85639CAS号:149838-21-1_PD-85639【结构式 性质 英文】 - 化源网 地址:https://m.chemsrc.com/mip/cas/149838-21-1_700158.html