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环氯胍

环氯胍用途

Cycloguanil hydrochloride 是 Proguanil 的活性代谢产物,作用于红细胞和肝细胞中的疟疾裂殖体。

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环氯胍名称

[ CAS 号 ]:
152-53-4

[ 中文名 ]:
1-(4-氯代苯)-6,6-二甲基-1,3,5-三氮-2,4二胺盐酸盐

[ 英文名 ]:
Cycloguanil Hydrochloride

[英文别名 ]:

CYCLOGUANIL HYDROCHLORIDE
BN 2410
Chloroguanide triazine hydrochloride

环氯胍生物活性

[ 描述 ]:

Cycloguanil hydrochloride 是 Proguanil 的活性代谢产物,作用于红细胞和肝细胞中的疟疾裂殖体。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200.

环氯胍物理化学性质

[ 沸点 ]:
400.7ºC at 760mmHg

[ 熔点 ]:
210-215ºC

[ 分子式 ]:
C₁₁H₁₅Cl₂N₅

[ 分子量 ]:
288.17600

[ 闪点 ]:
196.1ºC

[ 精确质量 ]:
287.07000

[ PSA ]:
80.00000

[ LogP ]:
2.66430

[ 蒸汽压 ]:
1.25E-06mmHg at 25°C

[ 储存条件 ]:
室温，干燥

环氯胍MSDS

详细MSDS(安全技术说明书)

环氯胍毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU2625000

CHEMICAL NAME :: Cycloguanil hydrochloride

CAS REGISTRY NUMBER :: 152-53-4

LAST UPDATED :: 199106

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H14-Cl-N5.Cl-H

MOLECULAR WEIGHT :: 288.21

WISWESSER LINE NOTATION :: T6N CN EN BHJ AR DG& B1 B1 DZ FZ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 54 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,487,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ATMPA2 Annals of Tropical Medicine and Parasitology. (Grune & Stratton, Inc., POB 6280, Duluth, MN 55806) V.1- 1907- Volume(issue)/page/year: 74,393,1980

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,487,1971

环氯胍

环氯胍用途

环氯胍名称

环氯胍生物活性

环氯胍物理化学性质

环氯胍MSDS

详细MSDS(安全技术说明书)

环氯胍毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

环氯胍安全信息

环氯胍上下游产品

环氯胍上游产品

环氯胍下游产品

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