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苄星青霉素

苄星青霉素用途

Penicillin G benzathine (Benzathine benzylpenicillin) 是一种能抗多种细菌感染的抗生素。

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苄星青霉素名称

[ CAS 号 ]:
1538-09-6

[ 中文名 ]:
苄星青霉素 G

[ 英文名 ]:
Penicillin G benzathine

[中文别名 ]:

[英文别名 ]:

leomypen
neolin
dibencil
benzathine benzylpenicillin
benzapen
moldamin
Megacillin
pendepon
DBED-penicillin
Penicillin G N,N'-dibenzylethylenediamine salt

苄星青霉素生物活性

[ 描述 ]:

Penicillin G benzathine (Benzathine benzylpenicillin) 是一种能抗多种细菌感染的抗生素。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Bowen AC, et al. Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial. Lancet. 2014 Dec 13;384(9960):2132-40.

苄星青霉素物理化学性质

[ 沸点 ]:
663.3ºCat 760 mmHg

[ 熔点 ]:
123-124ºC

[ 分子式 ]:
C₄₈H₅₆N₆O₈S₂

[ 分子量 ]:
909.124

[ 闪点 ]:
355ºC

[ 精确质量 ]:
908.360107

[ PSA ]:
248.08000

[ LogP ]:
5.72700

[ 蒸汽压 ]:
1.69E-18mmHg at 25°C

[ 储存条件 ]:
通风低温干燥

苄星青霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH9425000

CAS REGISTRY NUMBER :: 1538-09-6

LAST UPDATED :: 199707

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C32-H36-N4-O8-S2.C16-H20-N2

MOLECULAR WEIGHT :: 909.22

WISWESSER LINE NOTATION :: T45 ANV ESTJ CMV1R& F F GVQ & 2 &622

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,774,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,633,1954 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 22905 ug/kg

SEX/DURATION :: female 4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 82,1076,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1268 No. of Facilities: 49 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1896 (estimated) No. of Female Employees: 921 (estimated)

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苄星青霉素安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H334

[ 警示性声明 ]:
P261-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
XH9425000

苄星青霉素文献

Treatment of late-stage syphilis--reply.

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Treatment of late-stage syphilis.

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Clinical features and incidence rates of ocular complications in patients with ocular syphilis.

Am. J. Ophthalmol. 159(2) , 334-43.e1, (2015)

To describe the clinical outcomes of ocular syphilis.Retrospective chart review.The charts of patients with ocular syphilis (regardless of human immunodeficiency virus [HIV] status) seen in a uveitis ...

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