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羟高铁血红素

羟高铁血红素用途

血红素是一种含铁卟啉,通过与止血蛋白结合和失活的机制抑制凝血因子的活性和纤维蛋白凝块溶解[1]。血红素可用于急性卟啉症和癌症的研究[1][2][3][4][5]。

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羟高铁血红素名称

[ CAS 号 ]:
15489-90-4

[ 中文名 ]:
羟高铁血红素

[ 英文名 ]:
Hematin

[中文别名 ]:

[英文别名 ]:

Hydroxy[dihydrogen Protoporphyrin IX-ato(2-)]iron
ferriprotoporphyrin IX hydroxide
ferriporphyrin hydroxide
heme
BOVINE HEMIN
ferriheme hydroxide
ferrihemate
Hematin porcine
Hematin
ferriprotoporphyrin IX

羟高铁血红素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[体外研究]

血红素(0.01 mg/ml)抑制牛凝血酶(0.12 U/ml)凝结牛纤维蛋白原(1.3至2.6 mg/ml),并抑制人凝血酶水解合成底物[2]。血红素(0.035 mg/ml)可将VIII:C活性从0.88 U/ml降低至0.40 U/ml[2]。血红素(0.05 mg/ml)抑制凝血酶(0.04 U/ml)激活VIII:C[2]。血红素(0.09 mg/ml)抑制纤溶酶对合成底物的水解[2]。

[体内研究]

血红素(静脉注射；单次注射)抑制SD大鼠(体重160-205 g)[4]的卟啉生成。

[参考文献]

[1]. Siegert SW, et al. Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review. Adv Ther. 2008 Sep;25(9):842-57.

[2]. Green D, et al. The inactivation of hemostatic factors by hematin. J Lab Clin Med. 1983;102: 361-369.

[3]. Amin ML, et al. Development of hematin conjugated PLGA nanoparticle for selective cancer targeting. Eur J Pharm Sci. 2016 Aug 25;91:138-43.

[4]. Goetsch C, et al. Instability of hematin used in the treatment of acute hepatic porphyria. N Engl J Med. 1986;315: 235-238.

[5]. Quadros HC, et al. The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs. Pharmaceuticals (Basel). 2022;15(1):60. Published 2022 Jan 4.

羟高铁血红素物理化学性质

[ 沸点 ]:
1128.5ºC at 760 mmHg

[ 熔点 ]:
180ºC

[ 分子式 ]:
C₃₄H₃₃FeN₄O₅

[ 分子量 ]:
633.495

[ 闪点 ]:
636.3ºC

[ 精确质量 ]:
633.180054

[ PSA ]:
129.41000

[ LogP ]:
3.43290

[ 外观性状 ]:
暗晶体带有金属光泽

[ 蒸汽压 ]:
0mmHg at 25°C

[ 储存条件 ]:
2~8°C

羟高铁血红素MSDS

详细MSDS(安全技术说明书)

羟高铁血红素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NO6725000

CHEMICAL NAME :: Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipro pionato(2-))-hydroxy-

CAS REGISTRY NUMBER :: 15489-90-4

LAST UPDATED :: 199106

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C34-H31-Fe-N4-O5.2H

MOLECULAR WEIGHT :: 633.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 40 mg/kg/30D-I

TOXIC EFFECTS :: Cardiac - pulse rate increase, without fall in BP Vascular - BP elevation not characterized in autonomic section Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 101,877,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 43 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - hemorrhage

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 2,329,1978

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羟高铁血红素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

羟高铁血红素合成路线

详细合成路线

羟高铁血红素文献

In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives.

Antimicrob. Agents Chemother. 59 , 3271-80, (2015)

4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots. O-Acylation or O-alkylation of compound 1 provides derivatives exhibiting improved stabilit...

Glycan complexity dictates microbial resource allocation in the large intestine.

Nat. Commun. 6 , 7481, (2015)

The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which carbohydrate breakdown products are shared between m...

The Qiagen Investigator® Quantiplex HYres as an alternative kit for DNA quantification.

Forensic Sci. Int. Genet. 16 , 148-62, (2015)

The Investigator® Quantiplex HYres kit was evaluated as a potential replacement for dual DNA quantification of casework samples. This kit was determined to be highly sensitive with a limit of quantifi...

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羟高铁血红素相关知识

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大多数人都知道，铁元素是维持生命的主要物质，是制造血红素和肌血球素的主要物质，对机体生存起着极其重要的作用。为了满足大家对铁的需求，市面上出现了很多补铁剂。但很多人却不知道如何选择，也不懂用什么铁补血效果好。今天我们就来科普一下。　　一、膳食中的铁分类　　按照吸收机制与途径的不同，一般把膳食中的铁...