MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS: DNP-NH2 [MCA-RPKPVE-NVA-WRK: DNP-NH2]

用途

NFF-3是一种选择性MMP底物。NFF-3选择性地结合MMP-3和MMP-10以进行水解。NFF-3也被胰蛋白酶、肝细胞生长因子激活剂和因子Xa切割。用CyDye对Cy3/Cy5Q标记NFF-3,可以在细胞测定中产生荧光来检测细胞活性[1]。

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名称

[ CAS 号 ]:
158584-09-9

[ 中文名 ]:
MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS: DNP-NH2 [MCA-RPKPVE-NVA-WRK: DNP-NH2]

[ 英文名 ]:
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 trifluoroacetate salt

[中文别名 ]:

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 代谢酶/蛋白酶 >> MMP

[ 靶点 ]

MMP-3

MMP-10

[参考文献]

[1]. Giricz O, et al. Comparison of metalloproteinase protein and activity profiling. Anal Biochem. 2011 Feb 1;409(1):37-45.

物理化学性质

[ 分子式 ]:
C₇₈H₁₁₀N₂₂O₂₀

[ 分子量 ]:
1675.84

[ 精确质量 ]:
1674.83000

[ PSA ]:
662.53000

[ LogP ]:
8.39390

[ 外观性状 ]:
黄色至橙色粉末

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3).

J. Biol. Chem. 269 , 20952-20957, (1994)

Members of the matrix metalloproteinase (MMP) family have been implicated in disease states such as arthritis, periodontal disease, and tumor cell invasion and metastasis. Stromelysin 1 (MMP-3) has a ...

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