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N-(2,6-二甲基苯基)哌啶-2-甲酰胺

N-(2,6-二甲基苯基)哌啶-2-甲酰胺用途

Desbutylbupivacaine also known as N-Desbutyl Bupivacaine, it is a major metabolite of Bupivacaine.

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N-(2,6-二甲基苯基)哌啶-2-甲酰胺名称

[ CAS 号 ]:
15883-20-2

[ 中文名 ]:
N-(2',6'-二甲苯基 )-2-哌啶甲酰胺

[ 英文名 ]:
N-(2,6-Dimethylphenl)-2-Piperidine Carboxamide

[中文别名 ]:

[英文别名 ]:

UNII:NF8RN1V7VM
Mepivacaine impurity B
Desbutylbupivacaine
N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide
N-Desbutyl Bupivacaine
MFCD08458869
2',6'-Pipecoloxylidide
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-
N-(2,6-Dimethylphenyl)piperidine-2-carboxamide
N-(2',6'-Dimethylphenyl)-2-piperidinecarboxamide

N-(2,6-二甲基苯基)哌啶-2-甲酰胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
392.3±42.0 °C at 760 mmHg

[ 熔点 ]:
114-117ºC

[ 分子式 ]:
C₁₄H₂₀N₂O

[ 分子量 ]:
232.321

[ 闪点 ]:
149.0±28.0 °C

[ 精确质量 ]:
232.157562

[ PSA ]:
41.13000

[ LogP ]:
2.29

[ 外观性状 ]:
灰白色至淡黄色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.567

[ 储存条件 ]:
-20°C Freezer

N-(2,6-二甲基苯基)哌啶-2-甲酰胺MSDS

N-(2,6-二甲基苯基)哌啶-2-甲酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM6076000

CHEMICAL NAME :: 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-

CAS REGISTRY NUMBER :: 15883-20-2

BEILSTEIN REFERENCE NO. :: 0206391

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H20-N2-O

MOLECULAR WEIGHT :: 232.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974- Volume(issue)/page/year: 21,997,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0155176

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N-(2,6-二甲基苯基)哌啶-2-甲酰胺安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
Missing Phrase - N15.00950417

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
25

[ 安全声明 (欧洲) ]:
45

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ RTECS号 ]:
TM6076000

[ 海关编码 ]:
2933399090

N-(2,6-二甲基苯基)哌啶-2-甲酰胺合成路线

N-(2,6-二甲基苯基)哌啶-2-甲酰胺上下游产品

N-(2,6-二甲基苯基)哌啶-2-甲酰胺上游产品

N-(2,6-二甲基苯基)哌啶-2-甲酰胺下游产品

N-(2,6-二甲基苯基)哌啶-2-甲酰胺海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-(2,6-二甲基苯基)哌啶-2-甲酰胺文献

Kinetics of bupivacaine after clonidine pretreatment in mice.

Can. J. Anaesth. 42(5 Pt 1) , 434-7, (1995)

Previous studies have reported that clonidine pretreatment causes an increase in the local anaesthetic activity of bupivacaine. This study was designed to document possible changes in the pharmacokine...

Population pharmacokinetic analysis of ropivacaine and its metabolite 2',6'-pipecoloxylidide from pooled data in neonates, infants, and children.

Br. J. Anaesth. 107(3) , 409-24, (2011)

The aim was to characterize ropivacaine and 2',6'-pipecoloxylidide (PPX) pharmacokinetics and factors affecting them in paediatric anaesthesia.Population pharmacokinetics of ropivacaine and its active...

Bupivacaine kinetics during hyperthermia in rats.

Can. J. Anaesth. 41(3) , 253-6, (1994)

The aim of this study was to document possible alterations of bupivacaine pharmacokinetic behaviour in rats during hyperthermia. Two groups of Wistar AF IO PS male rats (Group A = normothermic control...

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