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焦碳酸二乙酯

焦碳酸二乙酯用途

焦碳酸二乙酯是一种有效的非特异性RNase化学抑制剂。焦碳酸二乙酯在体外作为一种相对特异于结合组氨酸咪唑的试剂很有用。焦碳酸二乙酯抑制家兔中枢化学敏感性。焦碳酸二乙酯可以修饰Ser、Thr、His和Tyr残基[1]。

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焦碳酸二乙酯名称

[ CAS 号 ]:
1609-47-8

[ 中文名 ]:
焦碳酸二乙酯

[ 英文名 ]:
Diethyl pyrocarbonate

[中文别名 ]:

[英文别名 ]:

Diethyl pyrocarbonate
MFCD00009106
ethoxycarbonyl ethyl carbonate
diethyl dicarbonate
DEP,DEPC,Diethyl dicarbonate
Diethyl pyrocarbonate (DEPC)
Diethyl oxydiformate
Ethoxyformic acid anhydride
EINECS 216-542-8

焦碳酸二乙酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. E E Nattie. Diethyl pyrocarbonate (an imidazole binding substance) inhibits rostral VLM CO2 sensitivity. J Appl Physiol (1985). 1986 Sep;61(3):843-50.

焦碳酸二乙酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
201.3±9.0 °C at 760 mmHg

[ 分子式 ]:
C₆H₁₀O₅

[ 分子量 ]:
162.141

[ 闪点 ]:
69.4±0.0 °C

[ 精确质量 ]:
162.052826

[ PSA ]:
61.83000

[ LogP ]:
1.48

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C

[ 折射率 ]:
1.413

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Combustible. Unstable - readily decomposes. Incompatible with strong oxidizing agents, strong acids, strong reducing agents, strong bases, ammonia.

[ 水溶解性 ]:
slow decomposition

焦碳酸二乙酯MSDS

焦碳酸二乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ9350000

CHEMICAL NAME :: Formic acid, oxydi-, diethyl ester

CAS REGISTRY NUMBER :: 1609-47-8

BEILSTEIN REFERENCE NO. :: 0637031

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C6-H10-O5

MOLECULAR WEIGHT :: 162.16

WISWESSER LINE NOTATION :: 2OVOVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZLUFAR Zeitschrift fuer Lebensmittel-Untersuchung und-Forschung. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.86- 1943- Volume(issue)/page/year: 114,292,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1558 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 ppm/1H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10 ppm/1H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 10 ppm/1H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972

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焦碳酸二乙酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
2810

[ WGK德国 ]:
3

[ RTECS号 ]:
LQ9350000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2920909090

焦碳酸二乙酯合成路线

焦碳酸二乙酯上下游产品

焦碳酸二乙酯上游产品

焦碳酸二乙酯下游产品

焦碳酸二乙酯海关

[ 海关编码 ]: 2920909090

[ 中文概述 ]:
2920909090 其他无机酸酯（不包括卤化氢的酯）（包括其盐及它们的卤化，磺化，硝化和亚硝化衍生物）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2920909090 esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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