3,4-二羟基苄胺氢溴酸

3,4-二羟基苄胺氢溴酸用途

3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) 是一种结构改良的多巴胺类似物细胞毒物,抑制黑色素瘤细胞中 DNA 聚合酶 (DNA polymerase) 活性。3,4-Dihydroxybenzylamine hydrobromide 在不同程度的酪氨酸酶活性的黑色素瘤细胞系中显示不同的生长抑制活性。

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3,4-二羟基苄胺氢溴酸名称

[ CAS 号 ]:
16290-26-9

[ 中文名 ]:
3,4-二羟基苄胺·氢溴酸

[ 英文名 ]:
3,4-DIHYDROXYBENZYLAMINE HYDROBROMIDE

[中文别名 ]:

[英文别名 ]:

EINECS 240-382-8
MFCD00012859
4-(aminomethyl)benzene-1,2-diol,hydrobromide
3,4-Dihydroxybenzylamine hydrobromide

3,4-二羟基苄胺氢溴酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

[体外研究]

3,4-二羟基苄胺氢溴酸盐(1μM-10 mM；48小时)抑制所有IC50为100μM的黑色素瘤细胞系的生长,而SK-MELB细胞系的IC50为122μM。人类SK-MEL-30、SK-MEL-2、SK-MEL-3、RPMI-7951细胞的IC50值分别为30、84、90和68μM。对于S91A、S91B、L1210和SCC-25细胞,其IC50值分别为10、25、67和184μM[2]。3,4-二羟基苄胺氢溴酸盐(1μM-10 mM；48小时)对SK-MEL-2和SK-MEL-28细胞株的细胞毒作用可通过应用丁硫磷亚砜胺(BSO)增强。BSO处理使边缘着色细胞对3,4-DHBA的作用敏感,SK-MEL-28细胞系中3,4-DHBA的IC50值降低127%,SK-MEL-2细胞系中降低148%。细胞活力测定[1]细胞系：人和小鼠黑色素瘤细胞系；非黑色素瘤细胞系浓度：1μM-10 mM培养时间：48小时结果：抑制黑色素瘤细胞系生长。

[体内研究]

3,4-二羟基苄胺氢溴化物(腹腔注射；1000 mg/kg；7天)对非荷瘤B6D2F1小鼠的毒性最小,并且小鼠在该剂量下耐受[3]。3,4-二羟基苄胺氢溴酸盐(腹腔注射；200-800mg/kg；21天)在不同剂量下有不同的作用,0 mg/kg、200 mg/kg、400 mg/kg、600 mg/kg和800 mg/kg的中位寿命分别为17、24.5、26、29和25天[3]。动物模型：B6D2F1细胞的C57BL/6小鼠[3]剂量：200 mg/kg、400 mg/kg、600 mg/kg和800 mg/kg给药：腹腔注射结果：200 mg/kg、400 mg/kg、600 mg/kg和800 mg/kg分别延长44%、46%、70%和50%的寿命。

[参考文献]

[1]. FitzGerald GB, et al. 3,4-Dihydroxybenzylamine: an improved dopamine analog cytotoxic for melanoma cells in part through oxidation products inhibitory to dna polymerase.J Invest Dermatol. 1983 Feb;80(2):119-23.

[2]. Prezioso JA1,et al.Effects of tyrosinase activity on the cytotoxicity of 3,4-dihydroxybenzylamine and buthionine sulfoximine in human melanoma cells.Pigment Cell Res. 1990 Mar-Apr;3(2):49-54.

[3]. Mlchael M. Wick,et al. 3,4-Dihydroxybenzylamine: Antitumor Activity Against A Dopamine Analog B16 Melanoma.

3,4-二羟基苄胺氢溴酸物理化学性质

[ 密度 ]:
1.309g/cm3

[ 沸点 ]:
333.4ºC at 760mmHg

[ 熔点 ]:
184-186 °C(lit.)

[ 分子式 ]:
C₇H₁₀BrNO₂

[ 分子量 ]:
220.06400

[ 闪点 ]:
155.5ºC

[ 精确质量 ]:
218.98900

[ PSA ]:
66.48000

[ LogP ]:
2.21490

[ 蒸汽压 ]:
1.32E-05mmHg at 25°C

[ 储存条件 ]:
室温，干燥

3,4-二羟基苄胺氢溴酸MSDS

详细MSDS(安全技术说明书)

3,4-二羟基苄胺氢溴酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922299090

3,4-二羟基苄胺氢溴酸上下游产品

3,4-二羟基苄胺氢溴酸上游产品

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3,4-二羟基苄胺氢溴酸海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3,4-二羟基苄胺氢溴酸文献

Simultaneous determination of electroactive and non-electroactive food preservatives by novel capillary electrophoresis with amperometric detection.

Anal. Chim. Acta 678(1) , 39-43, (2010)

A novel capillary electrophoresis and amperometric detection method was achieved by adding an electroactive additive (3,4-dihydroxybenzylamine, 3,4-DHBA) to the running buffer, so that both electroact...

Selective extraction of catecholamines by packed fiber solid-phase using composite nanofibers composing of polymeric crown ether with polystyrene.

Biomed. Chromatogr. 29(1) , 103-9, (2014)

For the first time, electrospun composite nanofibers comprising polymeric crown ether with polystyrene (PCE-PS) have been used for the selective extraction of catecholamines - dopamine (DA), norepinep...

ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells.

Cell. Signal. 28 , 177-89, (2016)

Extracellular signal-regulated kinases (ERKs) play important roles in proliferation, differentiation and gene expression. In our previous study, we demonstrated that both ERK5 and ERK1/2 were responsi...

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