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马拉氧磷

马拉氧磷用途

Malaoxon 是一种农药代谢物。 Malaoxon 可以诱导培养的人肺细胞的细胞死亡。 Malaoxon 可用于肺毒性研究。

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马拉氧磷名称

[ CAS 号 ]:
1634-78-2

[ 中文名 ]:
马拉氧磷

[ 英文名 ]:
Malaoxon

[中文别名 ]:

马拉代氧气磷

[英文别名 ]:

diethyl 2-[(dimethoxyphosphoryl)thio]succinate
Malathion impurity B
Liromat
Malathion-O-analog
Maloxon
rac-malaoxon
Diethyl 2-[(dimethoxyphosphoryl)sulfanyl]succinate
MFCD00055461
Malaoxone
Oxycarbophos

马拉氧磷生物活性

[ 描述 ]:

Malaoxon 是一种农药代谢物。 Malaoxon 可以诱导培养的人肺细胞的细胞死亡。 Malaoxon 可用于肺毒性研究。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Angelini DJ, et al. The Pesticide Metabolites Paraoxon and Malaoxon Induce Cellular Death by Different Mechanisms in Cultured Human Pulmonary Cells. Int J Toxicol. 2015 Sep-Oct;34(5):433-41.

马拉氧磷物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
376.0±52.0 °C at 760 mmHg

[ 熔点 ]:
<20℃

[ 分子式 ]:
C₁₀H₁₉O₇PS

[ 分子量 ]:
314.292

[ 闪点 ]:
181.2±30.7 °C

[ 精确质量 ]:
314.058899

[ PSA ]:
123.24000

[ LogP ]:
2.07

[ 外观性状 ]:
liquid

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.470

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

马拉氧磷MSDS

马拉氧磷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM8410000

CHEMICAL NAME :: Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethylphosphorothioate

CAS REGISTRY NUMBER :: 1634-78-2

LAST UPDATED :: 199806

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C10-H19-O7-P-S

MOLECULAR WEIGHT :: 314.32

WISWESSER LINE NOTATION :: 2OV1YVO2&SPO&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 158 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 119 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 8200 ug/kg

SEX/DURATION :: female 18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 umol/L

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 8,939,1981

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马拉氧磷安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H310

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P262-P280-P302 + P352 + P310-P361 + P364

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F,Xn,N,T

[ 风险声明 (欧洲) ]:
11-38-50/53-65-67-24/25

[ 安全声明 (欧洲) ]:
60-61-62-45-36/37/39-46-37-24

[ 危险品运输编码 ]:
UN 3018

[ RTECS号 ]:
WM8410000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

马拉氧磷合成路线

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马拉氧磷文献

Acetylcholinesterase immobilized on magnetic beads for pesticides detection: application to olive oil analysis.

Sensors (Basel.) 12(6) , 7893-904, (2012)

This work presents the development of bioassays and biosensors for the detection of insecticides widely used in the treatment of olive trees. The systems are based on the covalent immobilisation of ac...

Risk assessment of pesticides detected in surface water of the Alqueva reservoir (Guadiana basin, southern of Portugal).

Sci. Total Environ. 488-489 , 208-19, (2014)

The purpose of this study was to evaluate the potential impact of the pesticides detected in the Alqueva reservoir (Guadiana Basin, South Iberian Peninsula) on the aquatic organisms belonging to this ...

Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides.

Biol. Cell 13 , 343-63, (2008)

We have evaluated the potential of plasma albumin to provide a sensitive biomarker of exposure to commonly used organophosphorus pesticides in order to complement the widely used measure of acetylchol...

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