甘氨鹅脱氧胆酸钠

甘氨鹅脱氧胆酸钠用途

Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) 是一种从脱氧鹅胆酸和甘氨酸在肝脏中形成的胆汁盐。它起到洗涤剂的作用,可溶解脂肪吸收,并本身被吸收。Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) 可诱导肝细胞凋亡。

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甘氨鹅脱氧胆酸钠名称

[ CAS 号 ]:
16564-43-5

[ 中文名 ]:
甘鹅脱氧胆酸钠盐

[ 英文名 ]:
Glycochenodeoxycholic acid sodium

[中文别名 ]:

[英文别名 ]:

Sodium glycochenodeoxycholate
Glycochenodeoxycholic acid sodium salt

甘氨鹅脱氧胆酸钠生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Liang S, et al. Effect of quercetin 7-rhamnoside on glycochenodeoxycholic acid-induced L-02 human normal livercell apoptosis. Int J Mol Med. 2013 Aug;32(2):323-30.

[2]. Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207(1-2):19-27.

甘氨鹅脱氧胆酸钠物理化学性质

[ 沸点 ]:
655.6ºC at 760mmHg

[ 分子式 ]:
C₂₆H₄₂NNaO₅

[ 分子量 ]:
471.605

[ 闪点 ]:
350.3ºC

[ 精确质量 ]:
471.296082

[ PSA ]:
109.69000

[ LogP ]:
2.65030

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
5.74E-20mmHg at 25°C

[ 储存条件 ]:
室温，干燥

甘氨鹅脱氧胆酸钠MSDS

详细MSDS(安全技术说明书)

甘氨鹅脱氧胆酸钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

[ 海关编码 ]:
2924299090

甘氨鹅脱氧胆酸钠合成路线

详细合成路线

甘氨鹅脱氧胆酸钠上下游产品

甘氨鹅脱氧胆酸钠上游产品

甘氨鹅脱氧胆酸钠下游产品

甘氨鹅脱氧胆酸钠海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

甘氨鹅脱氧胆酸钠文献

Comprehensive comparison of cultivable norovirus surrogates in response to different inactivation and disinfection treatments.

Appl. Environ. Microbiol. 80(18) , 5743-51, (2014)

Human norovirus is the leading cause of epidemic and sporadic acute gastroenteritis. Since no cell culture method for human norovirus exists, cultivable surrogate viruses (CSV), including feline calic...

Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.

Drug Metab. Dispos. 43 , 851-63, (2015)

Inhibition of hepatic transporters such as organic anion transporting polypeptides (OATPs) 1B can cause drug-drug interactions (DDIs). Determining the impact of perpetrator drugs on the plasma exposur...

Mechanisms of cholesterol and saturated fatty acid lowering by Quillaja saponaria extract, studied by in vitro digestion model.

Food Funct. 6 , 1319-30, (2015)

Quillaja saponin extracts are known to reduce plasma cholesterol levels in humans. Here we study the mechanism of this effect with Quillaja Dry saponin extract (QD). In vitro model of triglyceride lip...

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