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硝碘酚腈

硝碘酚腈用途

Nitroxynil 是一种驱虫剂,能有效对抗在成年和未成熟阶段寄生虫。Nitroxynil 被广泛用于研究 Fasciola hepatica 的感染。

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硝碘酚腈名称

[ CAS 号 ]:
1689-89-0

[ 中文名 ]:
硝碘酚腈

[ 英文名 ]:
Nitroxynil

[中文别名 ]:

[英文别名 ]:

MFCD00070776
Dovenix
Nitroxynil
Benzonitrile, 4-hydroxy-3-iodo-5-nitro-
4-Hydroxy-3-iodo-5-nitrobenzonitrile
EINECS 216-884-8

硝碘酚腈生物活性

[ 描述 ]:

Nitroxynil 是一种驱虫剂,能有效对抗在成年和未成熟阶段寄生虫。Nitroxynil 被广泛用于研究 Fasciola hepatica 的感染。

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Holsback L, et, al. Anthelmintic efficiency of doramectin, fenbendazole, and nitroxynil, in combination or individually, in sheep worm control. Rev Bras Parasitol Vet. Jul-Sep 2016;25(3):353-8.

[2]. Takeba K, et, al. [Investigation of the residue of the fasciolicide nitroxynil in milk and dairy products]. Nihon Koshu Eisei Zasshi. 1992 Feb;39(2):75-82.

[3]. Na G, et, al. A rapid colloidal gold-based immunochromatographic strip assay for monitoring nitroxynil in milk. J Sci Food Agric. 2020 Mar 30;100(5):1860-1866.

硝碘酚腈物理化学性质

[ 密度 ]:
2.2±0.1 g/cm3

[ 沸点 ]:
280.1±40.0 °C at 760 mmHg

[ 熔点 ]:
136 - 139ºC

[ 分子式 ]:
C₇H₃IN₂O₃

[ 分子量 ]:
290.015

[ 闪点 ]:
123.2±27.3 °C

[ 精确质量 ]:
289.918823

[ PSA ]:
89.84000

[ LogP ]:
2.80

[ 外观性状 ]:
白色至黄色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.736

[ 储存条件 ]:
0-6°C

硝碘酚腈MSDS

详细MSDS(安全技术说明书)

硝碘酚腈毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI4600000

CHEMICAL NAME :: Benzonitrile, 4-hydroxy-3-iodo-5-nitro-

CAS REGISTRY NUMBER :: 1689-89-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H3-I-N2-O3

MOLECULAR WEIGHT :: 290.02

WISWESSER LINE NOTATION :: WNR BQ CI ECN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

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硝碘酚腈安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H317-H319-H335-H400

[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25;R36/37/38;R43

[ 安全声明 (欧洲) ]:
S26-S36/37-S45

[ 危险品运输编码 ]:
UN2811 6.1/PG 3

[ RTECS号 ]:
DI4600000

[ 海关编码 ]:
2926909090

硝碘酚腈上下游产品

硝碘酚腈上游产品

硝碘酚腈下游产品

硝碘酚腈海关

[ 海关编码 ]: 2926909090

[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

硝碘酚腈文献

In vitro metabolism of aromatic nitriles.

J. Pharm. Sci. 83(12) , 1729-34, (1994)

Studies on the metabolic fate of aromatic nitriles, in contrast to their aliphatic counterparts, have been minimal and the subject of controversy. The in vitro metabolic fate of several aromatic nitri...

Efficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle.

Vet. Parasitol. 162(3-4) , 278-84, (2009)

The objective was to compare the efficacy against artificially induced 2- and 4-week old early immature triclabendazole-susceptible liver flukes (Fasciola hepatica) of an injectable combination of nit...

Determination of nitroxynil residues in tissues using high-performance liquid chromatography-thermospray mass spectrometry.

Analyst 114(9) , 1013-5, (1989)

A method is described for the determination of nitroxynil residues in muscle, liver and kidney. The samples were extracted into diethyl ether and cleaned-up using a simple liquid-liquid extraction ste...

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