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(±)-Alpha-甲基-(4-四氮唑苯)日氨酸

(±)-Alpha-甲基-(4-四氮唑苯)日氨酸用途

MTPG是一种有效的mGluR2和mGluR3拮抗剂。MTPG可阻断脑缺血预处理诱导的脑缺血耐受。MTPG还显著减弱L-CCG-1对KCl诱发的多巴胺释放的抑制作用【1】。

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(±)-Alpha-甲基-(4-四氮唑苯)日氨酸名称

[ CAS 号 ]:
169209-66-9

[ 中文名 ]:
(±)-Alpha-甲基-(4-四氮唑苯)日氨酸

[ 英文名 ]:
MTPG

[中文别名 ]:

(±)-Α-甲基-(4-四氮唑苯)日氨酸

[英文别名 ]:

MFCD00672653
2-amino-2-[4-(tetrazol-1-yl)phenyl]propanoic acid

(±)-Alpha-甲基-(4-四氮唑苯)日氨酸生物活性

[ 描述 ]:

MTPG是一种有效的mGluR2和mGluR3拮抗剂。MTPG可阻断脑缺血预处理诱导的脑缺血耐受。MTPG还显著减弱L-CCG-1对KCl诱发的多巴胺释放的抑制作用【1】。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体

研究领域 >> 神经疾病

[ 靶点 ]

mGluR2, mGluR 3[1]

[参考文献]

[1]. Chaki S, et al. Group II metabotropic glutamate receptor-mediated regulation of dopamine release from slices of rat nucleus accumbens. Neurosci Lett. 2006;404(1-2):182-186.

[2]. Feng RF, Li WB, Liu HQ, et al. Sheng Li Xue Bao. 2003;55(3):303-310.

(±)-Alpha-甲基-(4-四氮唑苯)日氨酸物理化学性质

[ 分子式 ]:
C₁₀H₁₁N₅O₂

[ 分子量 ]:
233.23

[ 精确质量 ]:
233.09100

[ PSA ]:
106.92000

[ LogP ]:
0.62110

(±)-Alpha-甲基-(4-四氮唑苯)日氨酸MSDS

详细MSDS(安全技术说明书)

(±)-Alpha-甲基-(4-四氮唑苯)日氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

(±)-Alpha-甲基-(4-四氮唑苯)日氨酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(±)-Alpha-甲基-(4-四氮唑苯)日氨酸文献

New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord.

Neuropharmacology 34 , 851-856, (1995)

The depression of the monosynaptic excitation of neonatal rat motoneurones produced by the metabotropic glutamate receptor (mGluR) agonists (1S,3S)-1-aminocyclopentane-1, 3-dicarboxylate (ACPD) or L-2...

[Effects of alpha-methyl-(4-tetrazolyl-phenyl) glycine on the induction of hippocampal ischemic tolerance in the rat].

Sheng Li Xue Bao 55 , 303-10, (2003)

To explore the role of metabotropic glutamate receptor 2/3 mGluR 2/3 in the induction of brain ischemic tolerance (BIT), the influences of mGluR2/3 antagonist alpha-methyl-(4-tetrazolyl-phenyl) glycin...

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