WYE-687 dihydrochloride

WYE-687 dihydrochloride用途

WYE-687 dihydrochloride 是一种 ATP 竞争性的 mTOR 抑制剂,IC50 为 7 nM。WYE-687 dihydrochloride 抑制 mTORC1 和 mTORC2 活化。WYE-687 也抑制 PI3Kα 和 PI3Kγ,IC50 分别为 81 nM 和 3.11 μM。

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WYE-687 dihydrochloride名称

[ CAS 号 ]:
1702364-87-1

[ 英文名 ]:
WYE 687 dihydrochloride

WYE-687 dihydrochloride生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> PI3K/Akt/mTOR 信号通路 >> mTOR

研究领域 >> 癌症

信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K

[ 靶点 ]

mTOR:7 nM (IC50)

mTORC1

mTORC2

PI3K alpha:81 nM (IC50)

PI3K gamma:3.11 μM (IC50)

CK1 gamma1:17.8 μM (IC50)

p38 alpha:28.9 μM (IC50)

[参考文献]

[1]. Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40.

[2]. Cheng F, et al. Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent. Biochem Biophys Res Commun. 2016 Feb 5;470(2):324-330.

WYE-687 dihydrochloride物理化学性质

[ 分子式 ]:
C₂₈H₃₄Cl₂N₈O₃

[ 分子量 ]:
601.53

[ 储存条件 ]:
2-8°C，避光，干燥，密封

WYE-687 dihydrochloride安全信息

[ 危害码 (欧洲) ]:
Xi