野漆树苷

野漆树苷用途

Rhoifolin 是从琯溪蜜柚 (Citrus grandis) 叶子分离的黄酮糖苷。 Rhoifolin 通过增强脂联素分泌,胰岛素受体-β (insulin receptor-β) 的酪氨酸磷酸化和 GLUT4 易位有益于糖尿病并发症。 Rhoifolin 通过 RANKL 诱导的 NF-κB 和 MAPK 途径改善钛颗粒刺激的骨溶解并减弱破骨细胞生成。

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野漆树苷名称

[ CAS 号 ]:
17306-46-6

[ 中文名 ]:
野漆树苷

[ 英文名 ]:
Rhoifolin

[中文别名 ]:

漆叶甙

[英文别名 ]:

Apigenin-7-O-neohesperidoside
Apigenin-7-neohesperidoside
RHOIFOLOSIDE
Apigenin 7-O-neo-hesperidoside
apigenin 7-O-neohesperidoside
Rhoifolin
Apigenin-7-rhamnoglucoside

野漆树苷生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> MAPK/ERK信号通路 >> p38 MAPK

研究领域 >> 代谢疾病

信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体

[ 靶点 ]

NF-κB

insulin receptor-β

MAPK

[参考文献]

[1]. Rao YK, et al. Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells. Evid Based Complement Alternat Med. 2011;2011:624375.

[2]. Liao S, et al. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. J Cell Physiol. 2019 Aug;234(10):17600-17611.

野漆树苷物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
916.5±65.0 °C at 760 mmHg

[ 分子式 ]:
C₂₇H₃₀O₁₄

[ 分子量 ]:
578.519

[ 闪点 ]:
305.4±27.8 °C

[ 精确质量 ]:
578.163574

[ PSA ]:
228.97000

[ LogP ]:
1.72

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.726

[ 储存条件 ]:
0-6°C

野漆树苷MSDS

野漆树苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

野漆树苷合成路线

野漆树苷文献

Study on impurities in naringin extracted from Citrus grandis 'tomentosa'.

Zhong Yao Cai 35(1) , 56-61, (2012)

To investigate the impurities in naringin extracted from Citrus grandis 'Tomentosa'.High performance liquid chromatographies coupled with photodiode array and electrospray ionization mass spectrometry...

Determination of rhoifolin and daidzin in human plasma by high-performance liquid chromatography.

J. Chromatogr. B, Biomed. Appl. 655(2) , 300-4, (1994)

A method for determining flavonoids in human plasma is presented for application to pharmacokinetic studies of two flavonoids, rhoifolin and daidzin. Isocratic reversed-phase high-performance liquid c...

[Studies on antibacterial constituents of Discocleidion rufescens (2)].

Zhongguo Zhong Yao Za Zhi 34 , 1377-1380, (2009)

To screen effective constituents of Discocleidion rufescens against bacteria.Compounds were isolated by bioassay-guided fractionation method with various chromatographic methods and their structures w...

更多文献

野漆树苷

野漆树苷用途

野漆树苷名称

野漆树苷生物活性

野漆树苷物理化学性质

野漆树苷MSDS

详细MSDS(安全技术说明书)

野漆树苷安全信息

野漆树苷合成路线

详细合成路线

野漆树苷文献

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