野漆树苷

• 常用名: 野漆树苷
• 英文名: Rhoifolin
• CAS号: 17306-46-6
• 分子量: 578.519
• 密度: 1.7±0.1 g/cm3
• 沸点: 916.5±65.0 °C at 760 mmHg
• 分子式: C₂₇H₃₀O₁₄
• 熔点: N/A
• 闪点: 305.4±27.8 °C

野漆树苷用途

Rhoifolin 是从琯溪蜜柚 (Citrus grandis) 叶子分离的黄酮糖苷。 Rhoifolin 通过增强脂联素分泌,胰岛素受体-β (insulin receptor-β) 的酪氨酸磷酸化和 GLUT4 易位有益于糖尿病并发症。 Rhoifolin 通过 RANKL 诱导的 NF-κB 和 MAPK 途径改善钛颗粒刺激的骨溶解并减弱破骨细胞生成。

野漆树苷名称

• 中文名: 野漆树苷
• 英文名: apigenin 7-O-neohesperidoside
• 中文别名: 漆叶甙

野漆树苷生物活性

• 描述: Rhoifolin 是从琯溪蜜柚 (Citrus grandis) 叶子分离的黄酮糖苷。 Rhoifolin 通过增强脂联素分泌,胰岛素受体-β (insulin receptor-β) 的酪氨酸磷酸化和 GLUT4 易位有益于糖尿病并发症。 Rhoifolin 通过 RANKL 诱导的 NF-κB 和 MAPK 途径改善钛颗粒刺激的骨溶解并减弱破骨细胞生成。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 代谢疾病
  信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体
• 靶点实验:

  NF-κB

  insulin receptor-β

  MAPK

• 参考文献:

  [1]. Rao YK, et al. Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells. Evid Based Complement Alternat Med. 2011;2011:624375.

  [2]. Liao S, et al. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. J Cell Physiol. 2019 Aug;234(10):17600-17611.

野漆树苷物理化学性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 916.5±65.0 °C at 760 mmHg
• 分子式: C₂₇H₃₀O₁₄
• 分子量: 578.519
• 闪点: 305.4±27.8 °C
• 精确质量: 578.163574
• PSA: 228.97000
• LogP: 1.72
• InChIKey: RPMNUQRUHXIGHK-PYXJVEIZSA-N
• SMILES: CC1OC(OC2C(Oc3cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc4c3)OC(CO)C(O)C2O)C(O)C(O)C1O
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.726
• 储存条件: 0-6°C

野漆树苷MSDS

野漆树苷MSDS英文版

野漆树苷安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xi
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

野漆树苷靶点实验

查看更多实验

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Screen for inhibitors of RMI FANCM (MM2) intereaction 来源：11908 靶标：N/A External Id：RMI-FANCM-MM2

实验名称：HIV Enzyme Data 来源：NIAID 靶标：N/A External Id：HIV Enzyme Data

实验名称：Primary high throughput screening by co-culture imaging for identification hits as a ... 来源：23209 靶标：N/A External Id：UIHTS20180925

实验名称：Antioxidant activity assessed as inhibition of AAPH-induced hemolysis in rat RBC afte... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL992960

实验名称：Spectrum HTS for Inhibitors of Aerobactin Synthetase IucA 来源：23265 靶标：IucA Synthetase from hypervirulent Klebsiella pneumoniae hvKP1 External Id：IucA Pilot Assay Spectrum Library

实验名称：Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B3 External Id：CHEMBL3039491

实验名称：Inhibition of COX2 at 2.5 ug/mL 来源：ChEMBL 靶标：Prostaglandin G/H synthase 2 External Id：CHEMBL1008559

实验名称：The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre... 来源：11924 靶标：N/A External Id：CGM data for Cell Systems paper Dec 2015

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

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野漆树苷英文别名

• Apigenin-7-O-neohesperidoside
• Apigenin-7-neohesperidoside
• RHOIFOLOSIDE
• 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-on
• 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxyméthyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}tétrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphényl)-4H-chromén-4-one
• Apigenin 7-O-neo-hesperidoside
• 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside
• 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
• apigenin 7-O-neohesperidoside
• Rhoifolin
• Apigenin-7-rhamnoglucoside
• 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
• 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one