野漆树苷

• 常用名: 野漆树苷
• 英文名: Rhoifolin
• CAS号: 17306-46-6
• 分子量: 578.519
• 密度: 1.7±0.1 g/cm3
• 沸点: 916.5±65.0 °C at 760 mmHg
• 分子式: C₂₇H₃₀O₁₄
• 熔点: N/A
• 闪点: 305.4±27.8 °C

野漆树苷用途

Rhoifolin 是从琯溪蜜柚 (Citrus grandis) 叶子分离的黄酮糖苷。 Rhoifolin 通过增强脂联素分泌,胰岛素受体-β (insulin receptor-β) 的酪氨酸磷酸化和 GLUT4 易位有益于糖尿病并发症。 Rhoifolin 通过 RANKL 诱导的 NF-κB 和 MAPK 途径改善钛颗粒刺激的骨溶解并减弱破骨细胞生成。

野漆树苷名称

• 中文名: 野漆树苷
• 英文名: apigenin 7-O-neohesperidoside
• 中文别名: 漆叶甙

野漆树苷生物活性

• 描述: Rhoifolin 是从琯溪蜜柚 (Citrus grandis) 叶子分离的黄酮糖苷。 Rhoifolin 通过增强脂联素分泌,胰岛素受体-β (insulin receptor-β) 的酪氨酸磷酸化和 GLUT4 易位有益于糖尿病并发症。 Rhoifolin 通过 RANKL 诱导的 NF-κB 和 MAPK 途径改善钛颗粒刺激的骨溶解并减弱破骨细胞生成。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 代谢疾病
  信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体
• 靶点:

  NF-κB

  insulin receptor-β

  MAPK

• 参考文献:

  [1]. Rao YK, et al. Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells. Evid Based Complement Alternat Med. 2011;2011:624375.

  [2]. Liao S, et al. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. J Cell Physiol. 2019 Aug;234(10):17600-17611.

野漆树苷物理化学性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 916.5±65.0 °C at 760 mmHg
• 分子式: C₂₇H₃₀O₁₄
• 分子量: 578.519
• 闪点: 305.4±27.8 °C
• 精确质量: 578.163574
• PSA: 228.97000
• LogP: 1.72
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.726
• 储存条件: 0-6°C

野漆树苷MSDS

野漆树苷MSDS英文版

野漆树苷安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xi
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

野漆树苷英文别名

• Apigenin-7-O-neohesperidoside
• Apigenin-7-neohesperidoside
• RHOIFOLOSIDE
• 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-on
• 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-hydroxyphenyl)-
• 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxyméthyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}tétrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphényl)-4H-chromén-4-one
• Apigenin 7-O-neo-hesperidoside
• 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside
• 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-oxy]-5-hydroxy-2-(4-hydroxyphenyl)-
• 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
• apigenin 7-O-neohesperidoside
• Rhoifolin
• Apigenin-7-rhamnoglucoside
• 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
• 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
• 4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-