克林霉素

克林霉素用途

Clindamycin 是一种口服有效的蛋白质合成抑制剂,其具有以亚抑制浓度 (sub-MICs) 在金黄色葡萄球菌中毒力因子表达的能力。Clindamycin 的抗性是由 50S 核糖体亚基 (23S rRNA) 中抗生素结合位点的酶促甲基化产生。Clindamycin 降低杀白细胞毒素 (PVL),毒性休克-葡萄球菌毒素 (TSST-1) 或 α-溶血素 (Hla) 的产生。

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克林霉素名称

[ CAS 号 ]:
18323-44-9

[ 中文名 ]:
氯洁霉素

[ 英文名 ]:
Clindamycin

[中文别名 ]:

[英文别名 ]:

7-Deoxy-7(S)-chlorolincomycin
EINECS 242-209-1
Chlorodeoxylincomycin
Cleocin
Clindamycin
7-CDL
MFCD00072005
CLDM
dalacinc
Dalacine

克林霉素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Hodille E, et al. Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains. Ann Clin Microbiol Antimicrob. 2018 Oct 20;17(1):38.

克林霉素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
628.1±55.0 °C at 760 mmHg

[ 熔点 ]:
141 - 143ºC

[ 分子式 ]:
C₁₈H₃₃ClN₂O₅S

[ 分子量 ]:
424.983

[ 闪点 ]:
333.6±31.5 °C

[ 精确质量 ]:
424.179871

[ PSA ]:
127.56000

[ LogP ]:
1.83

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±4.2 mmHg at 25°C

[ 折射率 ]:
1.574

[ 储存条件 ]:
-20℃

克林霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RH6300000

CHEMICAL NAME :: L-threo-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2- pyrrolidinecarboxamido)-1-thio-, trans-alpha-

CAS REGISTRY NUMBER :: 18323-44-9

LAST UPDATED :: 199606

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H33-Cl-N2-O5-S

MOLECULAR WEIGHT :: 425.04

WISWESSER LINE NOTATION :: T6OTJ BS1 CQ DQ EQ FYYG1&MV- BT5NTJ A1 D3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2618 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RMVEAG Recueil de Medecine Veterinaire. (Masson Pub. USA, Inc., Year Book Medical Pub., 35 E. Wacker Dr., Chicago IL 60601) V.1- 1824- Volume(issue)/page/year: 156,915,1980

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 34,794,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 330 mg/kg/33D-I

TOXIC EFFECTS :: Gastrointestinal - other changes

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 28,18,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3191 No. of Facilities: 445 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 21575 (estimated) No. of Female Employees: 17442 (estimated)

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克林霉素相关知识

[克林霉素] -说明书-作用-克林霉素磷酸酯副作用

2019-01-10 17:39:44

导读：克林霉素是一种抗生素，可治疗中耳炎、骨关节发炎、骨盆腔发炎感染、链球菌咽炎、肺炎、心内膜炎等多种感染；有时也会用于治疗耐甲氧西林金黄色葡萄球菌（MRSA）造成的感染。克林霉素也被使用于青春痘的治疗；还可以和奎宁合并使用，治疗疟疾。克林霉素可以口服、静脉注射，也可以以药膏形式擦在皮肤、阴道。克...