CPPG

CPPG用途

CPPG ((RS)-CPPG) 是一种有效的 II/III 型 mGlu 受体拮抗剂。CPPG 对大鼠大脑皮层中的 III 组 (IC50=2.2 nM) 比对 II 组((IC50=46.2 nM) mGlu 受体有一定的选择性 (约 20 倍)。CPPG 对 I 组 mGlu 受体的作用较弱。

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CPPG名称

[ CAS 号 ]:
183364-82-1

[ 英文名 ]:
CPPG

[英文别名 ]:

CPPG
Water,sterile filtered

CPPG生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体

研究领域 >> 神经疾病

[体外研究]

CPPG((RS)-CPPG能同时逆转L-AP4(IC50=2.2nm)和L-CCG-I(IC50=46.2nm)介导的forskolin刺激的成年大鼠皮层脑片环腺苷酸积累的抑制作用。CPPG是抗成年大鼠皮层II/III型mGlu受体的有效拮抗剂,对III型mGlu受体具有中等的选择性。相反,CPPG对新生大鼠皮层和培养的小脑颗粒细胞中的mGlu受体的作用较弱[1]。

[参考文献]

[1]. Toms NJ, et al. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov;119(5):851-4.

CPPG物理化学性质

[ 分子式 ]:
C₁₁H₁₄NO₅P

[ 分子量 ]:
271.20600

[ 精确质量 ]:
271.06100

[ PSA ]:
130.66000

[ LogP ]:
0.83850

CPPG安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危险品运输编码 ]:
NONH for all modes of transport

CPPG文献

Examination of VLC-PUFA-deficient photoreceptor terminals.

Invest. Ophthalmol. Vis. Sci. 55(7) , 4063-72, (2014)

Juvenile-onset autosomal dominant Stargardt-like macular dystrophy (STGD3) is caused by mutations in ELOVL4 (elongation of very long fatty acids-4), an elongase necessary for the biosynthesis of very ...

Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies.

Neuropharmacology 102 , 276-94, (2016)

In the present study, we investigated the effect of ACPT-I [(1S, 3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid], a blood-brain-barrier permeable agonist of group III mGlu receptor, against oxyge...

Distinct effects of mGlu4 receptor positive allosteric modulators at corticostriatal vs. striatopallidal synapses may differentially contribute to their antiparkinsonian action.

Neuropharmacology 85 , 166-77, (2014)

Metabotropic glutamate 4 (mGlu4) receptor is a promising target for the treatment of motor deficits in Parkinson's disease (PD). This is due in part to its localization at key basal ganglia (BG) synap...

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