< 生产厂家价格 >

2-氯腺嘌呤

2-氯腺嘌呤用途

2-氯腺嘌呤(6-氨基-2-氯尿)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

点击显示

2-氯腺嘌呤名称

[ CAS 号 ]:
1839-18-5

[ 中文名 ]:
2-氯-6-氨基嘌呤

[ 英文名 ]:
2-chloroadenine

[中文别名 ]:

[英文别名 ]:

CHLOROADENINE
2-chlor-9h-purin-6-amin
7H-Purin-6-amine, 2-chloro-
6-amino-2-chloro-9H-purine
2-chloro-7h-purin-6-amine
6-amino-2-chloropurine
6-Amino-2-chloro-7H-purine
MFCD00127773
2-Chloro-1H-purin-6-amine
2-Chloroadenine

2-氯腺嘌呤生物活性

[ 描述 ]:

2-氯腺嘌呤(6-氨基-2-氯尿)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

2-氯腺嘌呤是一种杂环构建块,已被用于合成具有抗肿瘤活性的腺苷抗代谢产物。它也是 2个-氯-2英寸-脱氧腺苷的主要分解产物。

[参考文献]

[1]. Bauta, WE, Schulmeier, BE, Bur the , BJ, et al.A new process for antineoplastic agent clofarabineOrg. Proc. Res. Dev.8(6)889-896(2004)

[2]. Bontemps, F., Delacauw, A., Cardoen, S., et al. Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-29-deoxyadenosine Biochem. Pharmacol.59(10)1237-1243(2000)

2-氯腺嘌呤物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
485.5±27.0 °C at 760 mmHg

[ 熔点 ]:
>300°C(dec)

[ 分子式 ]:
C₅H₄ClN₅

[ 分子量 ]:
169.57

[ 闪点 ]:
247.4±23.7 °C

[ 精确质量 ]:
169.015518

[ PSA ]:
80.48000

[ LogP ]:
0.35

[ 外观性状 ]:
固体;White to Light yellow to Dark green powder to crystal

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.827

[ 储存条件 ]:
-20°C Freezer

2-氯腺嘌呤MSDS

详细MSDS(安全技术说明书)

2-氯腺嘌呤安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

2-氯腺嘌呤上下游产品

2-氯腺嘌呤上游产品

2-氯腺嘌呤下游产品

2-氯腺嘌呤海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-氯腺嘌呤文献

Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia.

Cancer Lett. 210(2) , 171-7, (2004)

The nucleoside analog 2-chlorodeoxyadenosine (Cladribine, CdA) is used in the treatment of patients with several hematological malignancies. After administration of CdA, the major catabolite measured ...

[Synthesis of 2-chloro-2'-deoxyadenosine by microbiological transglycosylation using a recombinant Escherichia coli strain].

Prikl. Biokhim. Mikrobiol. 44(2) , 181-6, (2008)

Cladribine (2-chloro-2'-deoxyadenosine) was synthesized using intact cells of the recombinant Escherichia coli strain producing Geobacillus stearothermophilus B-2194 thermostable purine-nucleoside pho...

Age-related changes in ischemic tolerance in male and female mouse hearts.

J. Mol. Cell. Cardiol. 38(2) , 245-56, (2005)

Aging is associated with reduced tolerance to ischemic insult, and genesis of this intolerant phenotype is poorly understood. We characterized effects of aging and gender on cardiovascular function an...

更多文献