2-氯腺苷

2-氯腺苷用途

2-Chloroadenosine 是一种腺苷类似物,可防止大鼠海马缺血细胞长期丢失。2-Chloroadenosine 是尿苷内流 (uridine influx) (表观 Ki=33 μM) 的竞争性抑制剂,高亲和力与硝基苄基硫肌苷结合 (表观 Ki=0.18 mM)。2-Chloroadenosine 是人红细胞核苷转运体的转运渗透剂。

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2-氯腺苷名称

[ CAS 号 ]:
146-77-0

[ 中文名 ]:
2-氯腺嘌呤核苷

[ 英文名 ]:
2-Chloroadenosine

[中文别名 ]:

2-氯腺苷

[英文别名 ]:

2-CADO,6-Amino-2-chloropurine riboside
2-Chloroadenosine
6-Amino-2-chloropurine Riboside Hydrate
2-CADO Hydrate
EINECS 205-678-3
MFCD00005734
Adenosine, 2-chloro-
2-Chlor-9-(β-D-ribofuranosyl)-9H-purin-6-amin
6-Amino-2-Chloropurine Riboside
2-chloro adenosine

2-氯腺苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Jarvis SM,2-Chloroadenosine, a permeant for the nucleoside transporter.Biochem Pharmacol. 1985 Sep 15;34(18):3237-41.

[2]. Evans MC, et al. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus.Neurosci Lett. 1987 Dec 29;83(3):287-92.

2-氯腺苷物理化学性质

[ 密度 ]:
2.2±0.1 g/cm3

[ 沸点 ]:
643.3±65.0 °C at 760 mmHg

[ 熔点 ]:
162 °C

[ 分子式 ]:
C₁₀H₁₂ClN₅O₄

[ 分子量 ]:
301.686

[ 闪点 ]:
342.8±34.3 °C

[ 精确质量 ]:
301.057770

[ PSA ]:
139.54000

[ LogP ]:
-0.46

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.912

[ 储存条件 ]:
库房低温通风干燥,与食品原料分开存放

[ 水溶解性 ]:
H2O: 10 mg/mL, clear, colorless

2-氯腺苷MSDS

2-氯腺苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7357550

CHEMICAL NAME :: Adenosine, 2-chloro-

CAS REGISTRY NUMBER :: 146-77-0

BEILSTEIN REFERENCE NO. :: 0043957

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H12-Cl-N5-O4

MOLECULAR WEIGHT :: 301.72

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ GG IZ D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 118,95,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 118,95,1959 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 603 ug/kg

SEX/DURATION :: female 11-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 25(2),35A,1982

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2-氯腺苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AU7357550

2-氯腺苷合成路线

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2-氯腺苷文献

Hypoxanthine uptake by skeletal muscle microvascular endothelial cells from equilibrative nucleoside transporter 1 (ENT1)-null mice: effect of oxidative stress.

Microvasc. Res. 98 , 16-22, (2015)

Adenosine is an endogenous regulator of vascular tone. This activity of adenosine is terminated by its uptake and metabolism by microvascular endothelial cells (MVEC). The predominant transporter invo...

Oxidative stress modulates nucleobase transport in microvascular endothelial cells

Microvasc. Res. 95 , 68-75, (2014)

Purine nucleosides and nucleobases play key roles in the physiological response to vascular ischemia/reperfusion events. The intra- and extracellular concentrations of these compounds are controlled, ...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

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