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SC 19220

SC 19220用途

SC-19220是一种竞争性前列腺素E2受体拮抗剂。SC-19220增加了氨基甲酸乙酯麻醉大鼠的膀胱容量,降低了排尿效率(由缓慢经膀胱充盈引起)。SC-19220可以恢复烧伤脓毒症后骨髓粒细胞和单核细胞生成的平衡[1][2]。
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SC 19220名称

[ CAS 号 ]:
19395-87-0

[ 英文名 ]:
SC 19220

[英文别名 ]:

SC 19220生物活性

[ 描述 ]:

SC-19220是一种竞争性前列腺素E2受体拮抗剂。SC-19220增加了氨基甲酸乙酯麻醉大鼠的膀胱容量,降低了排尿效率(由缓慢经膀胱充盈引起)。SC-19220可以恢复烧伤脓毒症后骨髓粒细胞和单核细胞生成的平衡[1][2]。

[ 相关类别 ]:

研究领域 >> 其他
信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

[ 靶点 ]

PGE2[1]


[参考文献]

[1]. Maggi CA, et al. The effect of SC-19220, a prostaglandin antagonist, on the micturition reflex in rats. Eur J Pharmacol. 1988 Aug 2;152(3):273-9.

[2]. Santangelo S, Shoup M, Gamelli RL, Shankar R. Prostaglandin E2 receptor antagonist (SC-19220) treatment restores the balance to bone marrow myelopoiesis after burn sepsis. J Trauma. 2000 May;48(5):826-30; discussion 830-1.

SC 19220物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 分子式 ]:
C16H14ClN3O3

[ 分子量 ]:
331.754

[ 精确质量 ]:
331.072357

[ PSA ]:
70.67000

[ LogP ]:
2.20

[ 折射率 ]:
1.624

[ 储存条件 ]:
-20°C,密闭,干燥

SC 19220MSDS

SC 19220安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

SC 19220文献

The role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats.

Cardiovasc. Res. 78(1) , 130-8, (2008)

The present study examined the hypothesis that prostaglandin E2 (PGE2) through activation of prostaglandin E (EP) receptor contributes to endothelium-dependent contractions.Western blotting revealed t...

Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.

PLoS ONE 7(9) , e45273, (2012)

Although prostanoids are known to be involved in regulation of the spontaneous beating rate of cultured neonatal rat cardiomyocytes, the various subtypes of prostanoid receptors have not been investig...

Prostaglandin E₂ possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts.

Prostaglandins Leukot. Essent. Fatty Acids 106 , 11-Aug, (2016)

We studied the role of PGE2, its biosynthetic enzymes and its receptors, in regulating the functions of lung fibroblasts through the production of Vascular Endothelial Growth Factor (VEGF) and Interle...


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公司名:上海化源世纪贸易有限公司

区域:上海市普陀区

价格:

联系人:徐经理

产品详情:SC-19220


公司名:上海脉铂医药科技有限公司

区域:上海市嘉定区

价格:
¥3749.0/10mg ¥15849.0/50mg ¥需询单/1g ¥需询单/1g

联系人:李先生

产品详情:SC 19220


公司名:上海创赛科技有限公司

区域:上海市嘉定区

价格:
¥1978.0/5mg ¥3684.8/10mg ¥15542.8/50mg

联系人:夏言

产品详情:[Perfemiker]SC-19220,98%


公司名:上海阿拉丁生化科技股份有限公司

区域:上海市浦东新区

价格:
¥7780.0/50mg ¥需询单/1g ¥需询单/1g ¥需询单/1g

联系人:阿拉丁

产品详情:SC 19220


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相关化合物

[SC 19220]化源网提供SC 19220CAS号19395-87-0,SC 19220MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询SC 19220上化源网,专业又轻松。>>电脑版:SC 19220

标题:【SC 19220】SC 19220 CAS号:19395-87-0【结构式 性质 活性】-化源网 地址:https://m.chemsrc.com/mip/cas/19395-87-0_1194851.html