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L-Glutamic acid γ-monohydroxamate

L-Glutamic acid γ-monohydroxamate用途

L-谷氨酰胺γ-单羟肟酸盐是一种抗肿瘤药物,抑制细胞增殖。L-谷氨酰胺γ-单羟肟酸选择性抑制L-组氨酸进入微血管内皮细胞。L-谷氨酰胺γ-单羟肟酸盐作为钒配体,激活葡萄糖摄取和代谢,从而降低体内血糖水平[1][2][3]。

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L-Glutamic acid γ-monohydroxamate名称

[ CAS 号 ]:
1955-67-5

[ 中文名 ]:
L-Glutamic acid γ-monohydroxamate

[ 英文名 ]:
L-GlutaMic acid γ-MonohydroxaMate

[英文别名 ]:

(4S)-4-Amino-4-carboxybutanehydroxamic acid
(2S)-5-amino-2-(hydroxyamino)-5-keto-valeric acid
N5-Hydroxy-L-glutamine
(S)-4-Amino-4-carboxybutanehydroximic acid
3-[2-Oxo-2-(hydroxyamino)ethyl]alanine
(2S)-2-Amino-5-oxo-5-(hydroxyamino)pentanoic acid
L-GlutaMic acid γ-MonohydroxaMate

L-Glutamic acid γ-monohydroxamate生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Vila J, et al. In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma. Int J Cancer. 1990 Apr 15;45(4):737-43.

[2]. Sakurai E, et al. Stereoselective transport of histidine in rat lung microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1192-7.

[3]. Goldwaser I, et al. L-Glutamic acid gamma-monohydroxamate. A potentiator of vanadium-evoked glucose metabolism in vitro and in vivo. J Biol Chem. 1999 Sep 10;274(37):26617-24.

L-Glutamic acid γ-monohydroxamate物理化学性质

[ 密度 ]:
1.432g/cm3

[ 沸点 ]:
553.6ºC at 760mmHg

[ 分子式 ]:
C₅H₁₀N₂O₄

[ 分子量 ]:
162.14400

[ 闪点 ]:
288.6ºC

[ 精确质量 ]:
162.06400

[ PSA ]:
116.14000

[ LogP ]:
0.22450

[ 蒸汽压 ]:
1.46E-14mmHg at 25°C

[ 折射率 ]:
1.538

[ 储存条件 ]:
-20°C

L-Glutamic acid γ-monohydroxamateMSDS

L-Glutamic acid γ-monohydroxamate安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2928000090

L-Glutamic acid γ-monohydroxamate合成路线

L-Glutamic acid γ-monohydroxamate上下游产品

L-Glutamic acid γ-monohydroxamate上游产品

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L-Glutamic acid γ-monohydroxamate海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

L-Glutamic acid γ-monohydroxamate文献

Cell differentiation of Proteus mirabilis is initiated by glutamine, a specific chemoattractant for swarming cells.

Mol. Microbiol. 8(1) , 53-60, (1993)

Swarming by Proteus mirabilis involves differentiation of typical short vegetative rods into filamentous hyperflagellated swarm cells which undergo cycles of rapid and co-ordinated population migratio...

Alternative substrates for wild-type and L109A E. coli CTP synthases: kinetic evidence for a constricted ammonia tunnel.

Eur. J. Biochem. 271(21) , 4204-12, (2004)

Cytidine 5'-triphosphate (CTP) synthase catalyses the ATP-dependent formation of CTP from uridine 5'-triphosphate using either NH(3) or l-glutamine as the nitrogen source. The hydrolysis of glutamine ...

Effect of epidermal growth factor on glutamine metabolic enzymes in small intestine and skeletal muscle of parenterally fed rats.

Nutrition 13(7-8) , 652-5, (1997)

Exogenous epidermal growth factor (EGF) markedly increases the in vivo uptake of glutamine by small intestine during total parenteral nutrition (TPN). Since glutamine is the major oxidative fuel for t...

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