谷氨酸钠_MSDS_用途_熔点_谷氨酸钠CAS号【142-47-2】

L-Glutamic acid monosodium salt(Monosodium glutamate) 是 mGlu1 受体活化剂。

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[ 描述 ]:

L-Glutamic acid monosodium salt(Monosodium glutamate) 是 mGlu1 受体活化剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体

研究领域 >> 神经疾病

[ 靶点 ]

mGlu1 receptor[1]

[体内研究]

向PND9小鼠单次全身注射L-谷氨酸单钠盐(MSG)(3μg/ kg)引起广泛的视网膜变性,并且相对于用盐水处理的对照小鼠,Brn-3a + RGC的数量减少> 70％;在用L-谷氨酸单钠盐和JNJ16259685处理的小鼠中,RGC的数量仅减少<20％,并且得到的值与包括对照小鼠在内的所有其他组小鼠中获得的值没有显着差异。向野生型BALB/c同窝仔畜施用L-谷氨酸单钠盐可使RGC数量降低至低于C57BL/6J小鼠的程度,但降低仍然非常显着[1]。

[动物实验]

对于毒性实验，如下处理PND9小鼠（每组n = 3-9只小鼠）。两组接受皮下（sc）注射玉米油，30分钟后，通过皮下注射生理盐水或L-谷氨酸单钠盐（3g / kg）;用3,4-二氢-2H-吡喃并[2,3-b]喹啉-7-基 - （顺式-4-甲氧基环己基） - 甲酮处理另外两组，溶于玉米油（2.5mg / kg）中。 30分钟后，通过皮下注射生理盐水或L-谷氨酸单钠盐。在另一组实验中，用盐水或L-谷氨酸单钠盐（3g / kg）皮下注射四组crv4小鼠或其野生型同窝小鼠（每组n = 5-7只小鼠）[1]。

[参考文献]

[1]. Liberatore F, et al. Permissive role for mglu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Sep 14. pii: S0306-4522(17)30640-1.

[相关活性小分子]

Mavoglurant | L-谷氨酰胺 | CTEP | (1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸 | ADX88178 | MPEP盐酸盐 | FITM | (S)-MCPG | Basimglurant | (2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 | 6-氟-2-[4-(吡啶-2-基)-3-丁炔基]咪唑并[1,2-A]吡啶 | JNJ-40411813 | (1R,4S,5S,6S)-4-氨基-2-硫杂双环[3.1.0]己烷-4,6-二甲酸 2,2-二氧化物 | JNJ16259685 | (S)-(4-氟苯基)-{3-[3-(4-氟苯基)-[1,2,4]二唑-5-基]哌啶-1-基}甲酮

[ 沸点 ]:
333.8ºC at 760 mmHg

[ 熔点 ]:
232°C

[ 分子式 ]:
C₅H₈NNaO₄

[ 分子量 ]:
169.111

[ 闪点 ]:
155.7ºC

[ 精确质量 ]:
169.035110

[ PSA ]:
103.45000

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
2.55E-05mmHg at 25°C

[ 折射率 ]:
25 ° (C=10, 2mol/L HCl)

[ 储存条件 ]:
室温

[ 水溶解性 ]:
>=10 g/100 mL at 20 ºC

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA1575000

CHEMICAL NAME :: Glutamic acid, monosodium salt, L-(+)-

CAS REGISTRY NUMBER :: 142-47-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 35

MOLECULAR FORMULA :: C5-H8-N-O4.Na

MOLECULAR WEIGHT :: 169.13

WISWESSER LINE NOTATION :: QVYZ2VO &-NA- -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 305,1154,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 43 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - hallucinations, distorted perceptions Gastrointestinal - nausea or vomiting

REFERENCE :: HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 36(9),364,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 3571 ug/kg

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,988,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 714 ug/kg

TOXIC EFFECTS :: Behavioral - headache

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 163,826,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 27,19,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4253 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - tetany

REFERENCE :: HSZPAZ Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie. (Walter de Gruyter, Inc., 200 Saw Mill River Rd., Hawthorne, NY 10532) V.21- 1895/96- Volume(issue)/page/year: 300,97,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5580 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,433,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - ataxia

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,433,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 227,214,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 227,214,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8200 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,433,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,424,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EbeAG# Personal Communication from A.G. Ebert, International Glutamate Technical Committee, 85 Walnut St., Watertown, MA 02172, Nov. 19, 1973 Volume(issue)/page/year: 19NOV1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,424,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24 mg/kg/6D-I

TOXIC EFFECTS :: Endocrine - hyperglycemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 45,195,1989 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1315 gm/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - hepatobiliary system Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,260,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 48 gm/kg

SEX/DURATION :: female 14 day(s) pre-mating - 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 50,267,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 19500 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

REFERENCE :: QUNUAZ Quaderni della Nutrizione. Notes on Nutrition. (North Cohocton, NY) V.1-31, 1934-71. Discontinued. Volume(issue)/page/year: 31,85,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 140 gm/kg

SEX/DURATION :: female 7-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - other postnatal measures or effects

REFERENCE :: IJNUB7 International Journal of Neuroscience. (Gordon & Breach Science Pub. S.A., 50 W. 23rd St., New York, NY 10010) V.1- 1970- Volume(issue)/page/year: 23,117,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 40 gm/kg

SEX/DURATION :: female 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 4,359,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 40 gm/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 4,359,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1 gm/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 1,207,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 34100 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: NETOD7 Neurobehavioral Toxicology. (Fayetteville, NY) V.1-2, 1979-80. For publisher information, see NTOTDY. Volume(issue)/page/year: 1,1,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5104 mg/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 14,77,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5104 mg/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 14,77,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 15 gm/kg

SEX/DURATION :: female 6 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 3,264,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 58 gm/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,69A,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 16 gm/kg

SEX/DURATION :: female 2 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 22,687,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 8 gm/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 17,404,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 20 gm/kg

SEX/DURATION :: female 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - oogenesis

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 14,362,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82886 No. of Facilities: 1087 (estimated) No. of Industries: 7 No. of Occupations: 11 No. of Employees: 21247 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82886 No. of Facilities: 2623 (estimated) No. of Industries: 18 No. of Occupations: 42 No. of Employees: 60341 (estimated) No. of Female Employees: 22829 (estimated)

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[ 危害码 (欧洲) ]:
O

[ 风险声明 (欧洲) ]:
R20/21/22

[ WGK德国 ]:
2

[ RTECS号 ]:
MA1578000

[ 海关编码 ]:
2922422000

详细合成路线

谷氨酸钠上游产品

谷氨酸钠下游产品

1.由谷氨酸中和、精制而得。将谷氨酸溶于水中，用含盐分少的碳酸钠或固体氢氧化钠中和至pH=6.7-7.0，温度不超过60℃。中和液经脱色去铁后进行真空浓缩、结晶、分离干燥而得成品。

目前国内外均采用以大米、淀粉或糖蜜为原料经糖化、发酵、提取和精制等工序制得：
(C6H10O5)_N[H2O]→C6H12O6[NH3,O2] →C5H9NO4[Na2CO3] →C5H8NnaO4
淀粉的糖化淀粉的糖化多采用双酶法。大米经浸泡、砂磨或淀粉直接调配成相对密度1.1(14°Bé)的淀粉浆；在Ph值4.5和90℃的条件下加入α-淀粉酶液化15～20min，然后升温至l00℃杀酶5min；放料后经板框压滤，滤渣可作饲料，滤液调至Ph值5.0，加入β-淀粉酶，在60℃下糖化12h；再升温至100℃杀酶后冷却澄清，上层清液直接放入糖液贮槽，沉淀液加助滤剂硅藻土后压滤，淀粉糖转化率可达92%。
谷氨酸发酵以15%左右的葡萄糖为碳源，并加适量的无机盐和生物素配成发酵培养基，经连消并冷却至40℃后送入已灭菌的发酵空罐；以流加的液氨为氮源，接种经二级扩大培养的谷氨酸产生菌，通风发酵30h；糖酸转化率可达50%，产酸水平约7.0%～7.5%。发酵过程Ph值控制在7.0～7.2，温度前期控制在32～34℃，后期34～37℃。
2.谷氨酸的提取谷氨酸的提取现一般采用冷冻等电一离子交换法。发酵液在等电罐中一边用冷冻盐水缓慢搅拌冷却降温至5"C，一边用硫酸调Ph值至3.22(等电点)；沉淀8h后，沉淀经离心分离得粗谷氨酸；母液和上层清液调配后上离子交换树脂交换，用氨水洗脱；前流分汇入上层清液重新上柱，后流分与氨水一起作洗脱液，高流分与发酵液一起回等电罐；提取收率可达88%～90%。
谷氨酸精制在装有60～6 5℃底水的中和罐中加入谷氨酸，搅拌，并缓慢加入纯碱溶液，中和至Ph值6.2～6.4，中和液浓度控制在相对密度1.1 7～1.18(21～2 2°Bé)；待中和液降温至50℃以下，加入适量的硫化钠溶液以除铁；然后用粗谷氨酸回调Ph值至6.2～6.4，并升温至60℃，再加入粉末活性炭，搅拌半小时后送入压滤机压滤；再将滤液用颗粒活性炭柱二次脱色得清液；清液送入真空煮晶锅内在60～70℃下蒸发浓缩至相对密度1.28(31.5084)，加入0.3 6～0.542mm的晶种后继续蒸发结晶，期间需用热水杀晶和补加一定量的清液；放料后，经育晶槽，再离心分离得结晶味精，母液或经脱色后再蒸发结晶，精制收率可达理论量的92%。

3.由发酵所得L-谷氨酸与氢氧化钠或碳酸钠中和后脱色精制而得。

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[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%