磺胺二甲异嘧啶钠

磺胺二甲异嘧啶钠用途

Sulfamethazine sodium (Sulfadimidine sodium) 是一种抗菌剂,可广泛用于治疗和预防各种动物疾病 (例如胃肠道和呼吸道感染)。在中国和欧盟委员会中,动物产品中 Sulfamethazine sodium 的最大残留量为 100 µg/kg。

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磺胺二甲异嘧啶钠名称

[ CAS 号 ]:
1981-58-4

[ 中文名 ]:
磺胺二甲嘧啶钠

[ 英文名 ]:
Sulfamethazine sodium salt

[中文别名 ]:

[英文别名 ]:

MFCD00068333
Sodium sulfametazine
Sodium sulfamezathine
Bovibol
sulfamethazine sodium
Sodium sulfamethiazine
sodium sulfamethazine
Sulfadimidine sodium
sodium sulfadimidinato
sulphadimidine sodium

磺胺二甲异嘧啶钠生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

Bacterial[1]

[体内研究]

磺胺甲嗪(80 mg/kg；静脉注射；健康雌性猪)治疗显着降低α,β和AUC0->∞,显着增加t1/2α,Vd和CIB,单次肌肉注射80 mg/kg磺胺甲嗪后猪的绝对生物利用度为1.01[1]。动物模型：19只健康雌性猪(6周龄,4.5-6.2 kg)[1]剂量：80 mg/kg给药：静脉注射(药代动力学研究)结果：分布期半衰期为0.23 h,半衰期消除期为9.8 h。α,β和AUC0->∞显着降低,t1/2α,Vd和CIB显着增加,猪的绝对生物利用度为1.01。

[参考文献]

[1]. VAN Poucke LSG, et al. Pharmacokinetics and Tissue Residues of Sulfathiazole and Sulfamethazine in Pigs. J Food Prot. 1994 Sep;57(9):796-801.

[2]. Sheng Y J, et al. Production of chicken yolk IgY to sulfamethazine: comparison with rabbit antiserum IgG. Food and Agricultural Immunology. 2015, 26(3):305-316.

磺胺二甲异嘧啶钠物理化学性质

[ 密度 ]:
1.392g/cm3

[ 沸点 ]:
526.2ºC at 760mmHg

[ 熔点 ]:
176ºC

[ 分子式 ]:
C₁₂H₁₃N₄NaO₂S

[ 分子量 ]:
300.312

[ 闪点 ]:
272.1ºC

[ 精确质量 ]:
300.065704

[ PSA ]:
97.56000

[ LogP ]:
2.99720

[ 外观性状 ]:
white to off-white

[ 蒸汽压 ]:
3.64E-11mmHg at 25°C

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: soluble50mg/mL

磺胺二甲异嘧啶钠MSDS

详细MSDS(安全技术说明书)

磺胺二甲异嘧啶钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WO9300000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(4,6-dimethyl-2-pyrimidinyl)-, monosodium salt

CAS REGISTRY NUMBER :: 1981-58-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H14-N4-O2-S.Na

MOLECULAR WEIGHT :: 301.35

WISWESSER LINE NOTATION :: T6NJ CNJ BMR D2SZW &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 974 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 699 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 605 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4891 No. of Facilities: 299 (estimated) No. of Industries: 2 No. of Occupations: 18 No. of Employees: 3501 (estimated) No. of Female Employees: 883 (estimated)

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磺胺二甲异嘧啶钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
WO9300000

[ 海关编码 ]:
2935009090

磺胺二甲异嘧啶钠海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

磺胺二甲异嘧啶钠文献

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DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.

Nucleic Acids Res. 39 , D1035-41., (2011)

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Depletion kinetics of 14C-sulfamethazine [4-amino-N-(4, 6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] metabolism in swine.

Drug Metab. Dispos. 14 , 161, (1986)

Swine weighing 60-70 kg were orally administered 14C-sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] at 12-hr intervals for 7 days (165 mg/dose; 0.126-5.04 mCi/mmol). ...

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