2(1H)-Quinolinone,7-hydroxy-4-methyl-

2(1H)-Quinolinone,7-hydroxy-4-methyl-用途

7-羟基-4-甲基-2(1H)-喹诺酮类(化合物2b)是一种荧光羟基化产物。7-羟基-4-甲基-2(1H)-喹诺酮类药物可用于检测DNA损伤的羟基自由基[1]。

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2(1H)-Quinolinone,7-hydroxy-4-methyl-名称

[ CAS 号 ]:
20513-71-7

[ 英文名 ]:
2(1H)-Quinolinone,7-hydroxy-4-methyl-

[英文别名 ]:

7-hydroxy-4-methyl-1H-quinolin-2-one

2(1H)-Quinolinone,7-hydroxy-4-methyl-生物活性

[ 描述 ]:

7-羟基-4-甲基-2(1H)-喹诺酮类(化合物2b)是一种荧光羟基化产物。7-羟基-4-甲基-2(1H)-喹诺酮类药物可用于检测DNA损伤的羟基自由基[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Tang VJ, et al. DNA Binding Hydroxyl Radical Probes. Radiat Phys Chem Oxf Engl 1993. 2012 Jan;81(1):46-51.

2(1H)-Quinolinone,7-hydroxy-4-methyl-物理化学性质

[ 密度 ]:
1.264 g/cm3

[ 沸点 ]:
417.8ºC at 760 mmHg

[ 熔点 ]:
≥250ºC(lit.)

[ 分子式 ]:
C₁₀H₉NO₂

[ 分子量 ]:
175.18400

[ 闪点 ]:
206.5ºC

[ 精确质量 ]:
175.06300

[ PSA ]:
53.09000

[ LogP ]:
1.54210

[ 蒸汽压 ]:
1.42E-07mmHg at 25°C

[ 折射率 ]:
1.611

2(1H)-Quinolinone,7-hydroxy-4-methyl-MSDS

2(1H)-Quinolinone,7-hydroxy-4-methyl-安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933790090

2(1H)-Quinolinone,7-hydroxy-4-methyl-合成路线

2(1H)-Quinolinone,7-hydroxy-4-methyl-上下游产品

2(1H)-Quinolinone,7-hydroxy-4-methyl-上游产品

2(1H)-Quinolinone,7-hydroxy-4-methyl-下游产品

2(1H)-Quinolinone,7-hydroxy-4-methyl-海关

[ 海关编码 ]: 2933790090

[ 中文概述 ]:
2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:9.0% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

2(1H)-Quinolinone,7-hydroxy-4-methyl-文献

On the metabolism of quinoline and isoquinoline: possible molecular basis for differences in biological activities.

Carcinogenesis 4 , 1169-1173, (1983)

Quinoline is a hepatocarcinogen in mice and rats, a mutagen in Salmonella typhimurium, and induces unscheduled DNA synthesis in primary cultures of rat hepatocytes. In contrast, isoquinoline has not b...

Microbial metabolism of quinoline and related compounds. XIX. Degradation of 4-methylquinoline and quinoline by Pseudomonas putida K1.

Biol. Chem. Hoppe-Seyler 374 , 479-488, (1993)

A bacterial strain, designated K1, which utilizes 4-methylquinoline and quinoline as sole source of carbon, nitrogen and energy was isolated from soil. Based on its morphological and physiological cha...

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