< 生产厂家价格 >

醋磺胺甲噁唑

醋磺胺甲噁唑用途

N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) 是磺胺甲恶唑 (HY-B0322) 的代谢物 (metabolite)。Sulfamethoxazole 是磺胺类抗菌素,用于细菌感染。

点击显示

醋磺胺甲噁唑名称

[ CAS 号 ]:
21312-10-7

[ 中文名 ]:
醋磺胺甲噁唑

[ 英文名 ]:
N4-Acetylsulfamethoxazole

[中文别名 ]:

N-乙酰磺胺甲恶唑

[英文别名 ]:

Sulfamethoxazole impurity A
N-Acetyl Sulfamethoxazole
N4-Acetylsulfamethoxazole
Sulfamethoxazole EP Impurity A

醋磺胺甲噁唑生物活性

[ 描述 ]:

N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) 是磺胺甲恶唑 (HY-B0322) 的代谢物 (metabolite)。Sulfamethoxazole 是磺胺类抗菌素,用于细菌感染。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 代谢疾病

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. https://pubchem.ncbi.nlm.nih.gov/compound/Acetylsulfamethoxazole

醋磺胺甲噁唑物理化学性质

[ 密度 ]:
1.448g/cm3

[ 熔点 ]:
222ºC dec.

[ 分子式 ]:
C₁₂H₁₃N₃O₄S

[ 分子量 ]:
295.31400

[ 精确质量 ]:
295.06300

[ PSA ]:
109.68000

[ LogP ]:
2.96900

[ 外观性状 ]:
棕色固体

[ 折射率 ]:
1.622

[ 储存条件 ]:
Refrigerator

醋磺胺甲噁唑MSDS

醋磺胺甲噁唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE4935000

CHEMICAL NAME :: Acetanilide, 4'-((5-methyl-3-isoxazolyl)sulfamoyl)-

CAS REGISTRY NUMBER :: 21312-10-7

BEILSTEIN REFERENCE NO. :: 0285801

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H13-N3-O4-S

MOLECULAR WEIGHT :: 295.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2690 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3471 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

点击显示

醋磺胺甲噁唑安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2935009090

醋磺胺甲噁唑合成路线

醋磺胺甲噁唑海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

醋磺胺甲噁唑文献

Excretion rates of sulfamethoxazole and N4-acetyl-sulfamethoxazole by fresh water turtles Pseudemys scripta elegans.

Vet. Q. 6(3) , 169-73, (1984)

Sulfamethoxazole and N4-acetylsulfamethoxazole are excreted by fresh water turtles Pseudemys scripta elegans in a biphasic mode, characterized half-lives of 5 and 100 min. Acetylation and deacetylatio...

Multiple-dose pharmacokinetics of 12 milligrams of trimethoprim and 60 milligrams of sulfamethoxazole per kilogram of body weight per day in healthy volunteers.

Antimicrob. Agents Chemother. 37(3) , 448-52, (1993)

The disposition of 12 mg of trimethoprim and 60 mg of sulfamethoxazole per kg of body weight in six healthy male volunteers is described. The daily dose was evenly divided and administered orally ever...

Sampling the lipogenic hepatic acetyl-CoA pool in vivo in the rat. Comparison of xenobiotic probe to values predicted from isotopomeric distribution in circulating lipids and measurement of lipogenesis and acetyl-CoA dilution.

J. Biol. Chem. 266(17) , 10912-9, (1991)

The acetylation of xenobiotics may provide a means for sampling hepatic cytosolic acetyl-CoA in vivo for isotopic studies of lipogenesis. Here, we test the accuracy of acetylated-sulfamethoxazole (SMX...

更多文献