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HEPARIN, SODIUM, LOW MOLECULAR WEIGHT

HEPARIN, SODIUM, LOW MOLECULAR WEIGHT用途

ICRF-193 是一种 TopoII 抑制剂。(S,S)- 和 (R,R)-ICRF-193 组成外消旋混合物 ICRF-196 (HY-118590A)。ICRF-196 可用于癌症研究。
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HEPARIN, SODIUM, LOW MOLECULAR WEIGHT名称

[ CAS 号 ]:
21416-88-6

[ 英文名 ]:
HEPARIN, SODIUM, LOW MOLECULAR WEIGHT

[英文别名 ]:

HEPARIN, SODIUM, LOW MOLECULAR WEIGHT生物活性

[ 描述 ]:

ICRF-193 是一种 TopoII 抑制剂。(S,S)- 和 (R,R)-ICRF-193 组成外消旋混合物 ICRF-196 (HY-118590A)。ICRF-196 可用于癌症研究。

[ 相关类别 ]:

研究领域 >> 癌症
信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶

[参考文献]

[1]. Snapka RM,et al. Inhibition of topoisomerase II by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane. Critical dependence on 2,3-butanediyl linker absolute configuration. Biochem Pharmacol. 1996;52(4):543-549.  

HEPARIN, SODIUM, LOW MOLECULAR WEIGHT物理化学性质

[ 分子式 ]:
C12H18N4O4

[ 分子量 ]:
282.30

[ 精确质量 ]:
282.13300

[ PSA ]:
105.80000

[ 蒸汽压 ]:
3.48E-11mmHg at 25°C

[ 储存条件 ]:
-20°C,密闭,干燥

HEPARIN, SODIUM, LOW MOLECULAR WEIGHTMSDS

HEPARIN, SODIUM, LOW MOLECULAR WEIGHT安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H317

[ 警示性声明 ]:
P280-P301 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 风险声明 (欧洲) ]:
22-43

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ RTECS号 ]:
TL6380200

HEPARIN, SODIUM, LOW MOLECULAR WEIGHT文献

DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193.

Mutat. Res. 530 , 35-46, (2003)

The bis-dioxopiperazine ICRF-193 has long time been considered as a pure topoisomerase II catalytic inhibitor able to exert its inhibitory effect on the enzyme without stabilization of the so-called c...

Decreased thymosin beta4 in apoptosis induced by a variety of antitumor drugs.

Biochem. Pharmacol. 57 , 1105, (1999)

As many antitumor drugs can kill tumors through the induction of apoptosis, the effect of these drugs presumably would be enhanced if they were used in combination with other drugs that interact with ...

Topoisomerase II poisoning by ICRF-193.

J. Biol. Chem. 276 , 44488-44494, (2001)

Antineoplastic bis(dioxopiperazine)s, such as meso-2,3-bis(2,6-dioxopiperazin-4-yl)butane (ICRF-193), are widely believed to be only catalytic inhibitors of topoisomerase II. However, topoisomerase in...


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推荐生产厂家/供应商:

公司名:上海化源世纪贸易有限公司

区域:上海市普陀区

价格:

联系人:徐经理

产品详情:ICRF-193


公司名:上海创赛科技有限公司

区域:上海市嘉定区

价格:
¥5845.0/1mg

联系人:夏言

产品详情:[Perfemiker]ICRF-193,98%


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