橙皮苷甲基查尔酮

橙皮苷甲基查尔酮用途

Hesperidin methylchalcone (Hesperidin methyl chalcone) 抑制氧化应激,细胞因子产生和 NF-κB 活化。Hesperidin methylchalcone 抑制炎症和疼痛。且具有血管保护活性。

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橙皮苷甲基查尔酮名称

[ CAS 号 ]:
24292-52-2

[ 中文名 ]:
甲基橙皮甙查尔酮

[ 英文名 ]:
Hesperidin methylchalcone

[中文别名 ]:

[英文别名 ]:

HESPERIDIN METHYL CHALCONE
HESPERIDIN METHYL CHALCONE*PRACTICAL GRA DE
EINECS 246-128-2
MFCD00010438
Hesperidine Methyl Chalcone

橙皮苷甲基查尔酮生物活性

[ 描述 ]:

Hesperidin methylchalcone (Hesperidin methyl chalcone) 抑制氧化应激,细胞因子产生和 NF-κB 活化。Hesperidin methylchalcone 抑制炎症和疼痛。且具有血管保护活性。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

NF-κB

[参考文献]

[1]. Pinho-Ribeiro FA, et al. Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: role of TRPV1, oxidative stress, cytokines and NF-κB. Chem Biol Interact. 2015 Feb 25;228:88-99.

橙皮苷甲基查尔酮物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
953.0±65.0 °C at 760 mmHg

[ 熔点 ]:
120 °C (dec.)(lit.)

[ 分子式 ]:
C₂₉H₃₆O₁₅

[ 分子量 ]:
624.587

[ 闪点 ]:
309.5±27.8 °C

[ 精确质量 ]:
624.205444

[ PSA ]:
234.29000

[ LogP ]:
1.86

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.672

[ 储存条件 ]:
2-8℃

橙皮苷甲基查尔酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FL7085000

CHEMICAL NAME :: Chalcone, 2',3,4'-trihydroxy-4,6'-dimethoxy-, 4'-(6-O-(6-deoxy-alpha-L-mannopyranosyl)- beta-D-glucopyranoside)

CAS REGISTRY NUMBER :: 24292-52-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C29-H36-O15

MOLECULAR WEIGHT :: 624.65

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: male 10 day(s) pre-mating female 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 118,657,1953

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橙皮苷甲基查尔酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
FL7085000

橙皮苷甲基查尔酮文献

Assessment of the antineoplastic potential of chalcones in animal models.

Curr. Med. Chem. 20(2) , 186-221, (2013)

One part of chemical space that is endowed with interesting biological properties is the area of the chalcones. With this review, we provide a comprehensive overview of the numerous in vivo animal stu...

Absorption and elimination of (14C) hesperidin methylchalcone in the rat.

Eur. J. Drug Metab. Pharmacokinet. 6(3) , 171-7, (1981)

Hesperidin methylchalcone resorption and excretion were studied in rats, using 14C-labelling. The level of radioactivity in the blood showed a peak 1-2 hours after oral administration of the labelled ...

Inhibitory effect of the Ruscus extract and of the flavonoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch.

J. Cardiovasc. Pharmacol. 22(2) , 225-30, (1993)

The Ruscus extract and the flavonoid hesperidine methylchalcone (HMC) are used in treatment of venous insufficiency. In the present study, we used the hamster cheek pouch preparation and investigated ...

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