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11-氨基十一酸

11-氨基十一酸用途

11-Aminoundecanoic acid 是一种 PROTAC 连接桥,属于 alkyl chain类。11-Aminoundecanoic acid 可用于合成一系列 PROTAC 分子。

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11-氨基十一酸名称

[ CAS 号 ]:
2432-99-7

[ 中文名 ]:
11-氨基十一酸

[ 英文名 ]:
11-Aminoundecanoic acid

[中文别名 ]:

[英文别名 ]:

H-11-Aun-OH
NH2-(CH2)10-COOH
Undecanoic acid, 11-amino-
11-Aminoundecansure
MFCD00008150
11-Amino-undecansaeure
aminoundecanoicacid
11-Aminoundecanoic a
EINECS 219-417-6
4-04-00-02823 (Beilstein Handbook Reference)

11-氨基十一酸生物活性

[ 描述 ]:

11-Aminoundecanoic acid 是一种 PROTAC 连接桥,属于 alkyl chain类。11-Aminoundecanoic acid 可用于合成一系列 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl-Chain

[参考文献]

[1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.

11-氨基十一酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
334.9±15.0 °C at 760 mmHg

[ 熔点 ]:
188-191 °C(lit.)

[ 分子式 ]:
C₁₁H₂₃NO₂

[ 分子量 ]:
201.306

[ 闪点 ]:
156.3±20.4 °C

[ 精确质量 ]:
201.172882

[ PSA ]:
63.32000

[ LogP ]:
2.55

[ 外观性状 ]:
白色结晶固体或粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.470

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
2 g/L (20 ºC)

11-氨基十一酸MSDS

11-氨基十一酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ2293000

CHEMICAL NAME :: Undecanoic acid, 11-amino-

CAS REGISTRY NUMBER :: 2432-99-7

BEILSTEIN REFERENCE NO. :: 1767291

LAST UPDATED :: 199701

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C11-H23-N-O2

MOLECULAR WEIGHT :: 201.35

WISWESSER LINE NOTATION :: Z10VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14700 ug/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 68250 mg/kg/13W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 655 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 328 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 500 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,239,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,239,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1682 No. of Facilities: 24 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1534 (estimated) No. of Female Employees: 1168 (estimated)

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11-氨基十一酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
52

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
YQ2293000

[ 海关编码 ]:
29224995

11-氨基十一酸合成路线

11-氨基十一酸上下游产品

11-氨基十一酸上游产品

11-氨基十一酸下游产品

11-氨基十一酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

11-氨基十一酸文献

Advanced material and approach for metal ions removal from aqueous solutions.

Sci. Rep. 5 , 8992, (2015)

A Novel approach to remove metals from aqueous solutions has been developed. The method is based on a resin free, solid, non-toxic, microcrystalline bisphosphonate material, which has very low solubil...

Development of 68Ga-labeled fatty acids for their potential use in cardiac metabolic imaging.

J. Labelled Comp. Radiopharm. 57(7) , 463-9, (2014)

While [(11)C]palmitate continues to be a promising tracer for cardiovascular Positron Emission Tomography (PET) imaging, unfavourable logistics due to the short half-life of (11)C (20 min) and cumbers...

Biocompatibility of Fe(3)O(4) nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells.

Nanotechnology 21 , 75102, (2010)

In order to reveal the biocompatibility of Fe(3)O(4) nanoparticles and bipolar surfactant tetramethylammonium 11-aminoundecanoate cytotoxicity tests were performed as a function of concentration from ...

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