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远志皂苷元

远志皂苷元用途

Tenuigenin 是从中草药远志 (Polygala tenuifolia) 根中分离出来的主要活性成分。Tenuigenin 通过抑制 NF-κB 活化来预防金黄色葡萄球菌诱导的肺炎。

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远志皂苷元名称

[ CAS 号 ]:
2469-34-3

[ 中文名 ]:
远志皂苷元

[ 英文名 ]:
Senegenin

[中文别名 ]:

遠志酸

[英文别名 ]:

Tennifolsaeure
Senegenin
tenuifolic acid
Tenuifolsaeure
Senegin

远志皂苷元生物活性

[ 描述 ]:

Tenuigenin 是从中草药远志 (Polygala tenuifolia) 根中分离出来的主要活性成分。Tenuigenin 通过抑制 NF-κB 活化来预防金黄色葡萄球菌诱导的肺炎。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

[ 靶点 ]

NF-κB

[体内研究]

Tenuigenin(2,4,8mg/kg)能显著减轻金黄色葡萄球菌诱导的肺组织病理学改变。Tenuigenin还可抑制BALB/c雄性小鼠肺湿/干(W/D)比、炎性细胞因子TNF-α和IL-1β的产生[1]。

[参考文献]

[1]. Yu B, et al. Protective effects of tenuigenin on Staphylococcus aureus-induced pneumonia in mice. Microb Pathog. 2017 Sep;110:385-389.

远志皂苷元物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
674.1±55.0 °C at 760 mmHg

[ 熔点 ]:
290-292ºC

[ 分子式 ]:
C₃₀H₄₅ClO₆

[ 分子量 ]:
537.128

[ 闪点 ]:
361.5±31.5 °C

[ 精确质量 ]:
536.290466

[ PSA ]:
115.06000

[ LogP ]:
6.39

[ 蒸汽压 ]:
0.0±4.7 mmHg at 25°C

[ 折射率 ]:
1.591

[ 储存条件 ]:
2-8C

远志皂苷元MSDS

详细MSDS(安全技术说明书)

远志皂苷元毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC8815000

CHEMICAL NAME :: 27-Noro-13-ene-23,28-dioic acid, 12-(chloromethyl)-2-beta,3-beta-dihydroxy-

CAS REGISTRY NUMBER :: 2469-34-3

BEILSTEIN REFERENCE NO. :: 2714357

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C30-H45-Cl-O6

MOLECULAR WEIGHT :: 537.20

WISWESSER LINE NOTATION :: L F6 E6 B666 EU- NTJ A1 D1G H1 H1 KVQ O1 SVQ S1 TQ UQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),259,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

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远志皂苷元安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
RC8815000